Importance of IL-18-Induced Super Th1 Cells for the Development of Allergic Inflammation

• Nakanishi Kenji

  Department of Immunology and Medical Zoology, Hyogo College of Medicine

• Tsutsui Hiroko

  Department of Microbiology, Hyogo College of Medicine

• Yoshimoto Tomohiro

  Laboratory of Allergic Diseases, Institute for Advanced Medical Sciences, Hyogo College of Medicine

抄録

Th1 cells, which express IL-18R, produce IFN-γ in response to Ag and IL-2 and increase further production of IFN-γ upon additional IL-18 stimulation. They simultaneously produce Th2 cytokines (IL-9 and IL-13), GM-CSF and chemokines (RANTES, MIP-1α). Human Th1 cells also produce IFN-γ and IL-13 in response to anti-CD3 and IL-18. Recently, we demonstrated Th1 cells induce intrinsic type atopic asthma and dermatitis by production of Th1- and Th2-cytokines and chemokines. Here, we review the pathological roles of Th1 cells, stimulated with Ag and IL-18 in vivo, in the pathogenesis of allergic disorders by production of Th1 and Th2 cytokines and chemokines. Based on this unique function of Ag- plus IL-18-stimulated Th1 cells, we proposed to designate them as "super Th1 cells".<br>

収録刊行物

• Allergology International

  Allergology International 59 (2), 137-141, 2010

  一般社団法人日本アレルギー学会

キーワード

• allergic inflammation
• atopic dermatitis
• bronchial asthma
• IL-18
• super Th1

詳細情報

• CRID: 1390001204632668928
• NII論文ID: 10029670054
• NII論文ID: 130004477079
• NII書誌ID: AA11091750
• DOI: 10.2332/allergolint.10-rai-0208
• COI: 1:CAS:528:DC%2BC3cXptVyktr8%3D
• ISSN: 14401592
• ISSN: 13238930
• PubMed: 20414054
• Web Site: http://api.elsevier.com/content/article/PII:S1323893015305852?httpAccept=text/xml
• Web Site: http://api.elsevier.com/content/article/PII:S1323893015305852?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/2010281824
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可