Impact of Sedative and Non-Sedative Antihistamines on the Impaired Productivity and Quality of Life in Patients with Pruritic Skin Diseases

• Murota Hiroyuki

  Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University

• Kitaba Shun

  Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University

• Tani Mamori

  Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University

• Wataya-Kaneda Mari

  Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University

• Azukizawa Hiroaki

  Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University

• Tanemura Atsushi

  Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University

• Umegaki Noriko

  Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University

• Terao Mika

  Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University

• Kotobuki Yorihisa

  Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University

• Katayama Ichiro

  Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University

抄録

Background: The impairment that pruritic skin diseases have on patient productivity at work, in the classroom, and in daily activities is substantial and needs to be characterized. The objective of this study was to determine how pruritic skin diseases impact patient productivity and quality of life (QOL), in order to improve the measurement of these endpoints to allow the influence of treatment options including sedative and non-sedative antihistamines to be analyzed.<br> Methods: The impact of pruritic skin diseases and the effect of antihistamine therapy on work, classroom, and daily productivity were evaluated using the Work Productivity Assessment Index-Allergy Specific Questionnaire. The intensity of itch and patient QOL were assessed using a visual analogue scale and Skindex-16, respectively.<br> Results: Pruritic skin diseases resulted in significant impairment of work, classroom, and daily productivity. The severity of overall work impairment in atopic dermatitis (AD), urticaria, and prurigo was higher than for other diseases analyzed. However, classroom activity was more adversely affected in patients with urticaria relative to other diseases. All pruritic diseases in this study negatively impacted daily activity to a similar degree. Impaired productivity was significantly improved in patients taking non-sedative antihistamines for 1 month, and the improvements correlated with the alleviation of itch and improved QOL.<br> Conclusions: These results indicate that pruritic skin diseases reduce patient productivity at work, in the classroom, and during daily activities, and that non-sedative antihistamines may offer an advantage over sedative antihistamines for alleviating certain negative consequences of these skin diseases.<br>

収録刊行物

• Allergology International

  Allergology International 59 (4), 345-354, 2010

  一般社団法人日本アレルギー学会

キーワード

• antihistamine
• productivity
• pruritic
• quality-of-life
• skin diseases
• WPAI-AS

詳細情報

• CRID: 1390001204631936768
• NII論文ID: 10029671061
• NII書誌ID: AA11091750
• DOI: 10.2332/allergolint.10-oa-0182
• ISSN: 14401592
• ISSN: 13238930
• PubMed: 20864795
• Web Site: http://api.elsevier.com/content/article/PII:S1323893015306456?httpAccept=text/xml
• Web Site: http://api.elsevier.com/content/article/PII:S1323893015306456?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/2011149703
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可