培養細胞における温熱化学療法の基礎的検討

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  • In vitro Effects of Hyperthermia Combined with Chemotherapeutic Agents.

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Interactive effects of combined treatment with hyperthermia and chemotherapeutic agents were interpreted in the experimental aspects of medical science. Survey of literature and our own studies indicate that cytotoxicity of alkylating agents, cisplatin, bleomycin and mitomycin C (MMC) can be enhanced at elevated temperatures. However, the thermal enhancement of doxorubicin (Dox) is complicated or even doubtful against tumors, because Dox could potentially enhance production of heat-induced hsps that may cause the certain mechanism in the development of thermotolerance. Comparative studies indicated that the thermal enhancement of MMC cytotoxicity is marked and the development of thermotolerance was partially inhibited by MMC. An interesting observation is that the cytotoxicity of some drugs are enhanced by mild hyperthermia. In this regards, cisplatin (CDDP) potentiates cellular thermosensitivity at 42°C by enhancing heat-induced apoptosis. These findings are significant in use of chemotherapy together with mild hyperthermia which can avoid potential heat-induced normal tissue damage followed by the local or regional hyperthermia.

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