ディーゼル排気ナノ粒子のステロイド合成系への影響とメカニズム  [in Japanese] Effects of Nanoparticle-Rich-Diesel Exhaust on Steroidogenesis in Rats and the Mechanism Underlying Such Effects  [in Japanese]

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Author(s)

    • 山岸 希 YAMAGISHI Nozomi
    • 名古屋大学大学院医学系研究科環境労働衛生学 Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine
    • 伊藤 由起 ITO Yuki
    • 名古屋大学大学院医学系研究科環境労働衛生学 Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine
    • 那須 民江 NAKAJIMA Tamie
    • 名古屋大学大学院医学系研究科環境労働衛生学 Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine

Abstract

Diesel exhaust (DE) is one of the major air pollutants in the world. DE disrupts steroid hormone levels, which may result from the disruption of spermatogenesis. Steroidogenesis occurs not only in the testis but also in the brain. Therefore, we investigated the effects of nanoparticle-rich DE (NR-DE) on steroidogenesis in both the testis and hippocampus. Exposure to NR-DE at concentrations comparable to the environmental standard for particulate matters 2.5 (PM<sub>2.5</sub>) in Japan increased plasma testosterone level. This exposure increased the expression levels of genes involved in steroidogenesis in the testis, but not in the hippocampus, suggesting that NR-DE disrupts steroid hormone balance. This finding suggests the need to reconsider the environmental limit of PM<sub>2.5</sub> in Japan.<br>

Journal

  • Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene)

    Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene) 66(4), 634-637, 2011-09-15

    The Japanese Society for Hygiene

References:  22

Codes

  • NII Article ID (NAID)
    10029679753
  • NII NACSIS-CAT ID (NCID)
    AN00185923
  • Text Lang
    JPN
  • Article Type
    REV
  • ISSN
    00215082
  • NDL Article ID
    11270148
  • NDL Source Classification
    ZS17(科学技術--医学--衛生学・公衆衛生)
  • NDL Call No.
    Z19-194
  • Data Source
    CJP  NDL  J-STAGE 
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