Newly Bioactive Peptide “Kisspepitin” and Its Role for the Neuronal Regulation System for Reproduction

• Ozawa Hitoshi

  Department of Anatomy and Neurobiology, Graduate School of Medicine, Nippon Medical School

• Takumi Ken

  Department of Anatomy and Neurobiology, Graduate School of Medicine, Nippon Medical School

• Sawai Nobuhiko

  Department of Anatomy and Neurobiology, Graduate School of Medicine, Nippon Medical School

• Iwata Kinuyo

  Department of Anatomy and Neurobiology, Graduate School of Medicine, Nippon Medical School

• Nakane Ryo

  Department of Anatomy and Neurobiology, Graduate School of Medicine, Nippon Medical School

• Iijima Norio

  Department of Anatomy and Neurobiology, Graduate School of Medicine, Nippon Medical School

Bibliographic Information

Other Title

• 新規生理活性物質キスペプチンKisspeptinと性機能調節神経系
• 新規生理活性物質キスペプチンKisspeptinと性機能調節神経系--新しい間脳(視床下部)-下垂体-性腺系機能概念の構築
• シンキ セイリ カッセイ ブッシツ キスペプチン Kisspeptin ト セイ キノウ チョウセツ シンケイケイ アタラシイ カン ノウ シショウカブ カスイタイ セイセンケイ キノウ ガイネン ノ コウチク
• ~New Aspect of Hypothalamus-Pituitary-Gonad (HPG) Axis~
• ～新しい間脳（視床下部）―下垂体―性腺系機能概念の構築～

Abstract

A newly reported bioactive peptide, kisspeptin and its receptor (Kiss1r or GPR54) have an important role as key player in the regulation of reproduction. Mutations of the peptide and its receptor cause profound hypothalamic hypogonadotropic hypogonadism. Kisspeptin neurons are expressed in the hypothalamus, as well as other brain region in many vertebrates. Kisspeptin neurons directly project to GnRH neurons and may stimulate to secrete GnRH. Kisspeptin neurons show sexually difference with respect to the number of neurons and transcription activity in certain nuclei in the brain, and some kisspeptin neurons coexpress other transmitters, dynorphin and neurokinin B. Kisspeptin signaling system mediated by estrogen via estrogen receptor a has been related in mediateing the positive and negative feedback action of sex steroids on LH/FSH secretion, generating the preovulatory GnRH and/or LH surge, and triggering and guiding the onset of puberty.In this review, we introduce the morphological characteristics and many important physiological function of kisspeptin and its receptor.

Journal

• KENBIKYO

  KENBIKYO 46 (2), 111-118, 2011-06-30

  The Japanese Society of Microscopy

Keywords

• Kisspepitin
• Kisspeptin receptor (Kiss1r or GPR54)
• GnRH
• Puberty
• Reproductive regulation

Details

• CRID: 1390002184856082176
• NII Article ID: 10029694620
• NII Book ID: AA11917781
• DOI: 10.11410/kenbikyo.46.2_111
• ISSN: 24342386
• ISSN: 13490958
• NDL BIB ID: 11178550
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I11178550
• Web Site: https://search.jamas.or.jp/link/ui/2011284269
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed