ブタ由来エラスチンペプチドの経口摂取によるマウス皮膚水分含量の向上  [in Japanese] Effect of porcine arterial elastin peptide to the moisture content of mice skin  [in Japanese]

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Abstract

ブタ大動脈よりエラスチンの酵素加水分解ペプチド(エラスチンペプチド)を調製し,その摂取が皮膚にもたらす影響について検討した.生後7週の雄ヘアレスマウスにエラスチンペプチドなどの試料を経口投与し,63日間の飼育を行った.皮膚老化モデルとして光老化モデルを採用し,週3回の頻度で紫外線を照射した.照射52日目および55日目にエラスチンペプチドとコラーゲンペプチドを混合投与した群およびコラーゲンペプチド投与群において,皮膚水分量が照射対照群に比べて有意に上昇し,エラスチンペプチドの単独投与群において上昇傾向が認められた.エラスチンペプチドやコラーゲンペプチドの単独投与に比べ,皮膚中の存在比やそれに近い比での混合投与による相乗効果が得られ,光老化に対する皮膚症状の改善が認められた.つまり,エラスチンペプチドがコラーゲンペプチドの摂取による皮膚水分量の上昇効果を増強することが示唆された.

We prepared hydrolysate of elastin from porcine aorta and evaluated its effect on skin by oral administration. In this study, the photoaging model which hairless mice were exposed by ultraviolet-B was adopted as a model of skin aging. Seven-week-old male hairless mice were fed a commercial diet and water for 63 days, and a hydrolysate dissolved in distilled water was adiministered. Ultraviolet-B irradiations were done 3 times per week. Moisture content of back skin was measured once or twice per week. After the administration term, skin pieces were taken from back of mouse, and then histopathological analysis was done and amino acid composition of skin was determined. Significant increases of skin moisture were observed in groups of the mixture of elastin peptide and collagen peptide and of collagen peptide after 52 and 55 days. In the administration of elastin peptide, skin moisture tended to increase. From the histopathological analysis, thickness of epidermis induced by ultrabiolet-B irradiation was depressed by the administration of the mixture of elastin and collagen peptide. Desmosine and isodesmosine content in skin was also depressed by the administration of the mixture of elastin and collagen peptide and of the collagen peptide only, while those of control mice irradiated ultraviolet-B was increased. Compared with each administration of elastin peptide and collagen peptide, the administration of mixture of these peptides in ratio of these skin contents or near ratio gave synergism, and then the improvement of skin condition, such as skin moisture and thickness of epidermis, against photoaging was observed. These results indicated that elastin peptide increased the effect of the administration of collagen peptide on skin moisture.

Journal

  • Nihon Chikusan Gakkaiho

    Nihon Chikusan Gakkaiho 80(2), 215-222, 2009-05-25

    Japanese Society of Animal Science

References:  11

Cited by:  2

Codes

  • NII Article ID (NAID)
    10029740282
  • NII NACSIS-CAT ID (NCID)
    AN00195188
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    1346907X
  • NDL Article ID
    10319600
  • NDL Source Classification
    ZR22(科学技術--農林水産--畜産)
  • NDL Call No.
    Z18-348
  • Data Source
    CJP  CJPref  NDL  IR  J-STAGE 
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