ブタ由来エラスチンペプチドの経口摂取によるマウス皮膚水分含量の向上 [in Japanese] Effect of porcine arterial elastin peptide to the moisture content of mice skin [in Japanese]
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We prepared hydrolysate of elastin from porcine aorta and evaluated its effect on skin by oral administration. In this study, the photoaging model which hairless mice were exposed by ultraviolet-B was adopted as a model of skin aging. Seven-week-old male hairless mice were fed a commercial diet and water for 63 days, and a hydrolysate dissolved in distilled water was adiministered. Ultraviolet-B irradiations were done 3 times per week. Moisture content of back skin was measured once or twice per week. After the administration term, skin pieces were taken from back of mouse, and then histopathological analysis was done and amino acid composition of skin was determined. Significant increases of skin moisture were observed in groups of the mixture of elastin peptide and collagen peptide and of collagen peptide after 52 and 55 days. In the administration of elastin peptide, skin moisture tended to increase. From the histopathological analysis, thickness of epidermis induced by ultrabiolet-B irradiation was depressed by the administration of the mixture of elastin and collagen peptide. Desmosine and isodesmosine content in skin was also depressed by the administration of the mixture of elastin and collagen peptide and of the collagen peptide only, while those of control mice irradiated ultraviolet-B was increased. Compared with each administration of elastin peptide and collagen peptide, the administration of mixture of these peptides in ratio of these skin contents or near ratio gave synergism, and then the improvement of skin condition, such as skin moisture and thickness of epidermis, against photoaging was observed. These results indicated that elastin peptide increased the effect of the administration of collagen peptide on skin moisture.
- Nihon Chikusan Gakkaiho
Nihon Chikusan Gakkaiho 80(2), 215-222, 2009-05-25
Japanese Society of Animal Science