Novel Taxa-4(20),12-diene and 2(3.RAR.20)Abeotaxane from Needles of Taxus canadensis

• NI Zhi-Yu

  College of Basic Medicine, Hebei Medical University

• WU Yi-Bing

  School of Pharmaceutical Sciences, Hebei Medical University

• ZHANG Man-Li

  School of Pharmaceutical Sciences, Hebei Medical University

• WANG Yu-Fang

  School of Pharmaceutical Sciences, Hebei Medical University

• DONG Mei

  College of Basic Medicine, Hebei Medical University

• SAURIOL Françoise

  Department of Chemistry, Queen’s University

• HUO Chang-Hong

  School of Pharmaceutical Sciences, Hebei Medical University

• SHI Qing-Wen

  School of Pharmaceutical Sciences, Hebei Medical University

• GU Yu-Cheng

  Jealott’s Hill International Research Centre

• KIYOTA Hiromasa

  Graduate School of Agricultural Science, Tohoku University

• CONG Bin

  College of Basic Medicine, Hebei Medical University

Bibliographic Information

Other Title

• Novel taxa-4(20),12-diene and 2(3→20)Abeotaxane from needles of Taxus canadensis
• Novel taxa 4 20 12 diene and 2 3 20 Abeotaxane from needles of Taxus canadensis
• Novel Taxa-4(20),12-diene and 2(3→20)<i>Abeo</i>taxane from Needles of<i>Taxus canadensis</i>

Abstract

A novel 6/8/6-membered taxane with a rare C-12(13)-double bond and rare 2(3→20)abeotaxane were isolated from the needles of Taxus canadensis. Their structures were characterized as 7β,9α,10β-triacetoxytaxa-4(20),12-diene-2α,5α,11β-triol (1) and 2α,7β,10β-triacetoxy-5α-hydroxy-2(3→20)abeotaxa-4(20),11-diene-9,13-dione (2) on the basis of 1D and 2D spectroscopic data. 1 is the first example of a natural taxane without substitution at both C-13 and C-14.

Journal

• Bioscience, Biotechnology, and Biochemistry

  Bioscience, Biotechnology, and Biochemistry 75 (9), 1698-1701, 2011

  Japan Society for Bioscience, Biotechnology, and Agrochemistry

Keywords

• <I>Taxus canadensis</I>
• needle
• taxane
• taxa-4(20),12-diene
• isolation

Details

• CRID: 1390282681456474368
• NII Article ID: 10029756977
• NII Book ID: AA10824164
• DOI: 10.1271/bbb.110223
• ISSN: 13476947
• ISSN: 09168451
• NDL BIB ID: 11252675
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I11252675
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.110223
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed