リン酸八カルシウム骨前駆体の調製とアパタイトへの転化特性評価

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タイトル別名
  • Preparation and Evaluation of Octacalcium Phosphate Bone Precursor Transformable to Apatite
  • リンサン 8 カルシウムコツ ゼンクタイ ノ チョウセイ ト アパタイト エ ノ テンカ トクセイ ヒョウカ

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Reaction of an aqueous suspension of dicalcium phosphate dihydrate (DCPD) and calcium carbonate at 30 - 80°C was applied to prepare octacalcium phosphate (OCP) powder expected to be a bone precursor in accord with bone remodeling process. XRD analysis confirmed that the reaction temperature and reaction time strongly exert an influence on a crystalline form of prepared OCP. OCP synthesized at 60°C showed a characteristic stability to time changes. Increasing reaction temperature however resulted in the rapid decomposition of OCP to hydroxyapatite (HAp) because of the consecutive reaction DCPD→OCP→HAp. OCP powders were immersed in simulated body fluid (SBF) to evaluate its transformation ability to HAp. SEM micrographs and EDS analysis demonstrated that calcium-deficient HAp should be crystallized after the dissolution of OCP into SBF. OCP synthesized at 60°C was transformed to HAp rapidly after the immersion time of 21 days.

収録刊行物

  • 粉体工学会誌

    粉体工学会誌 48 (9), 600-605, 2011

    一般社団法人 粉体工学会

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