Artesunate, a potential drug for treatment of Babesia infection

• Goo, Youn-Kyoung

• Terkawi, M. Alaa

• Jia, Honglin

• Aboge, G. Oluga

• Ooka, Hideo

• Kim, Suk

• Igarashi, Ikuo

• Nishikawa, Yoshifumi

• Xuan, Xuenan

Abstract

The effect of artesunate, a water-soluble artemisinin derivative, against Babesia species, such as Babesia bovis, Babesia gibsoni, and Babesia microti was studied. Cultures of B. bovis and B. gibsoni were treated with 0.26 μM, 2.6 μM, 26 μM, and 260 μM artesunate, and the growth-inhibitory effect was shown in over 2.6 μM artesunate in day 4 and day 3 post-subculture for B. bovis and B. gibsoni, respectively, in dose-dependent manner. In vivo experiment for B. microti, strong inhibition effects were observed in mouse groups treated with over 1.0 mg/kg body weight of artesunate on day 9 and 10 post-infection. These results suggest that artesunate could be a potential drug for Babesia infection.

Journal

• Parasitology International

  Parasitology International 59 (3), 481-486, 2010-09

  Elsevier

Keywords

• Artesunate
• Babesia bovis
• Babesia gibsoni
• Babesia microti

Details

• CRID: 1050282812560577920
• NII Article ID: 10029825801
• NII Book ID: AA11112001
• ISSN: 13835769
• Web Site: https://obihiro.repo.nii.ac.jp/records/780
• Web Site: https://search.jamas.or.jp/link/ui/2011054278
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • CiNii Articles