飼料に添加したタウロケノデオキシコール酸がニジマスの肝臓組織に及ぼす影響  [in Japanese] Influence of Dietary Chenodeoxycholyltaurine on Liver Morphology in Fingerling Rainbow Trout, Oncorhynchus mykiss  [in Japanese]

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Abstract

大豆油粕(SBM)主体飼料を給餌したニジマスに生じる肝臓の組織変性と胆汁中のタウロケノデオキシコール酸(CDC-T)の増加との関連を明らかにするため,CDC-Tを添加したカゼイン主体半精製飼料を6週間給餌したニジマスの肝臓組織と胆汁塩組成について検討した。SBM主体飼料区およびCDC-Tを0.5%添加した飼料区(0.5CDC-T区)では胆のう胆汁中のCDC-Tの割合が対照飼料区より増加していた。CDC-Tを0.05%添加した飼料区では肝細胞に萎縮がみられなかったが,0.5%CDC-T区では肝細胞の萎縮が認められ,その組織像はSBM区に類似していた。以上のことから,SBM飼料を給餌したニジマスの肝臓組織変性には胆汁中のCDC-Tの増加が関与している可能性が考えられた。

In rainbow trout, <I>Oncorhynchus mykiss</I>, fed defatted soybean meal-based diets, increase of chenodeoxycholyltaurine (CDC-T) in the biliary bile as well as histological changes in the liver occurs. To investigate a possible involvement of biliary CDC-T on the occurrence of morphological abnormalities in the liver of rainbow trout fed soybean meal-based diets, histological observations were conducted on fish fed a casein-based semi-purified diet supplemented with CDC-T. A control diet (Cont), and two test diets supplemented with CDC-T at 0.05% (0.05CDC-T) and 0.5% (0.5CDC-T), and a soybean meal-based diet (SBM), were fed to rainbow trout for 6 weeks. The proportions of biliary CDC-T of fish fed diet SBM and diet 0.5CDC-T were higher than fish fed diet Cont. Hepatocytes of fish fed diet 0.05CDC-T seemed normal. However, the hepatocytes of fish fed diet 0.5CDC-T were atrophied, and the hepatic histological features of this group were similar to those found in fish fed diet SBM. These results suggest that increase of biliary CDC-T is probably a responsible factor for the occurrence of histological changes in the liver of rainbow trout fed soybean meal-based diets.

Journal

  • Aquaculture Science

    Aquaculture Science 57(3), 507-512, 2009-09-20

    Japanese Society for Aquaculture Science

References:  12

Cited by:  1

Codes

  • NII Article ID (NAID)
    10029845141
  • NII NACSIS-CAT ID (NCID)
    AN00124667
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    03714217
  • NDL Article ID
    10449009
  • NDL Source Classification
    ZR26(科学技術--農林水産--水産)
  • NDL Call No.
    Z18-761
  • Data Source
    CJP  CJPref  NDL  IR  J-STAGE 
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