Dietary Vitamin E Deficiency Increases Anxiety-Like Behavior in Juvenile and Adult Rats
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- TERADA Yuki
- Department of Agricultural Chemistry, Faculty of Agriculture, Meiji University
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- OKURA Yuki
- Department of Agricultural Chemistry, Faculty of Agriculture, Meiji University
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- KIKUSUI Takefumi
- Companion Animal Research, School of Veterinary Medicine, Azabu University
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- TAKENAKA Asako
- Department of Agricultural Chemistry, Faculty of Agriculture, Meiji University
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Vitamin E deficiency from birth or infancy has recently been found to increase anxiety-like behavior in rodents. The present study was undertaken to elucidate the effect of dietary vitamin E deficiency on anxiety in adult rats in comparison with juvenile rats. Male Wistar rats, 3 or 10 weeks old, were divided into two groups and fed a control or vitamin E-deficient diet for 4 weeks. The results of behavioral analysis revealed that vitamin E-deficiency increased anxiety in both juvenile and adult rats. Plasma, liver, and brain α-tocopherol concentrations decreased significantly due to vitamin E deficiency in both age groups. Plasma corticosterone concentrations were higher in the vitamin E-deficient rats in response to the stress of a behavioral test. Based on these results, we conclude that dietary vitamin-E deficiency induces anxiety in adult rats as well as juvenile rats. This might be due to an elevated plasma corticosterone concentration.
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 75 (10), 1894-1899, 2011
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390282681454521984
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- NII論文ID
- 10029872564
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- NII書誌ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 11286318
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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