Serotonergic Modulation of Absence-Like Seizures in Groggy Rats : a Novel Rat Model of Absence Epilepsy

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Abstract

To explore the role of the serotonergic system in modulating absence seizures, we examined the effects of 5-HT<SUB>1A</SUB> and 5-HT<SUB>2</SUB> agonists on the incidence of spike-and-wave discharges (SWD) in Groogy (GRY) rats, a novel rat model of absence-like epilepsy. GRY rats exhibited spontaneous absence-like seizures characterized by the incidence of sudden immobile posture and synchronously-associated SWD. The total duration of SWD in GRY rats was about 300 – 400 s/15-min observation period under the control conditions. However, the incidence of SWD was markedly reduced either by the 5-HT<SUB>1A</SUB> agonist (±)-8-hydroxy-2-(di-<I>n</I>-propylamino)-tetralin [(±)8-OH-DPAT] or the 5-HT<SUB>2</SUB> agonist (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane [(±)DOI]. The 5-HT reuptake inhibitors, fluoxetine and clomipramine, also inhibited the SWD generation. In addition, the inhibitory effects of (±)8-OH-DPAT and (±)DOI were reversed by WAY-100135 (5-HT<SUB>1A</SUB> antagonist) and ritanserin (5-HT<SUB>2</SUB> antagonist), respectively. The present results suggest that the serotonergic system negatively regulates the incidence of absence seizures by stimulation of 5-HT<SUB>1A</SUB> and 5-HT<SUB>2</SUB> receptors.

Journal

  • Journal of Pharmacological Sciences

    Journal of Pharmacological Sciences 114(1), 99-105, 2010-09-20

    The Japanese Pharmacological Society

References:  38

Codes

  • NII Article ID (NAID)
    10029889960
  • NII NACSIS-CAT ID (NCID)
    AA11806667
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    13478613
  • NDL Article ID
    10823467
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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