Electrophysiological and pharmacological characteristics of triggered activity elicited in the guinea-pig pulmonary vein myocardium
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- Takahara Akira
- Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
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- Sugimoto Takahiko
- Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
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- Kitamura Takuma
- Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
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- Takeda Kiyoshi
- Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
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- Tsuneoka Yayoi
- Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
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- Namekata Iyuki
- Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
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- Tanaka Hikaru
- Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
書誌事項
- タイトル別名
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- Electrophysiological and Pharmacological Characteristics of Triggered Activity Elicited in Guinea-Pig Pulmonary Vein Myocardium
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The pulmonary vein is known as an important source of ectopic beats, initiating frequent paroxysms of atrial fibrillation. We analyzed electrophysiological and pharmacological characteristics of triggered activity elicited in the isolated pulmonary vein from the guinea pig. Immediately after the termination of train stimulation (pacing cycle length of 100 ms), spontaneous activities accompanied with phase-4 depolarization were detected in 43 out of 45 pulmonary vein preparations. Such triggered activities were not observed in the isolated left atrium. The incidence of triggered activity was higher at a shorter pacing cycle length (100 – 200 ms), and the coupling interval was shorter at a shorter pacing cycle length. Verapamil (1 μM), ryanodine (0.1 μM), and pilsicainide (10 μM) suppressed the occurrence of triggered activities. The resting membrane potential of the pulmonary vein myocardium was more positive than that of the left atrium. Carbachol (0.3 μM) hyperpolarized the resting membrane potential and completely inhibited the occurrence of triggered activities. These results suggest that the pulmonary veins have more arrhythmogenic features than the left atrium, possibly through lower resting membrane potential. The electrophysiological and pharmacological characteristics of triggered activity elicited in the pulmonary vein myocardium were similar to those previously reported using ventricular tissues.
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 115 (2), 176-181, 2011
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282680158054400
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- NII論文ID
- 10029892032
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- NII書誌ID
- AA11806667
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- COI
- 1:CAS:528:DC%2BC3MXivVKrtLg%3D
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- ISSN
- 13478648
- 13478613
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- NDL書誌ID
- 10979790
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- PubMed
- 21258174
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可