Developmental Changes in Action Potential Prolongation by K+-Channel Blockers in Chick Myocardium

DOI Web Site 参考文献22件
  • Nouchi Hideaki
    Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
  • Kiryu Naoaki
    Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
  • Kimata Mikio
    Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
  • Tsuneoka Yayoi
    Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
  • Hamaguchi Shogo
    Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
  • Namekata Iyuki
    Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
  • Takahara Akira
    Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
  • Shigenobu Koki
    Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
  • Tanaka Hikaru
    Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan

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The effects of K+-channel blockers on the action potential duration of the myocardium were examined in isolated right ventricles from the 7 – 10-day-old, 11 – 13-day-old, and 14 – 20-day-old embryo and 1 – 7-day-old hatched chicks. E-4031 significantly prolonged action potential duration at all developmental stages examined; the prolongation was largest in the 11 – 13-day-old embryo and was accompanied by early after-depolarizations. Chromanol 293B showed smaller prolongation at all stages examined. Terfenadine prolonged action potential duration in the 11 – 13-day-old embryo, but not in other stages. Thus, the chick ventricular myocardium changes its repolarization properties during development.

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