The mechanism underlying the synergetic hypocholesterolemic effect of sesamin and α-tocopherol in rats fed a high-cholesterol diet

• Rogi Tomohiro

  Institute for Health Care Science, Suntory Wellness Limited, Japan

• Tomimori Namino

  Institute for Health Care Science, Suntory Wellness Limited, Japan

• Ono Yoshiko

  Institute for Health Care Science, Suntory Wellness Limited, Japan

• Kiso Yoshinobu

  Institute for Health Care Science, Suntory Wellness Limited, Japan

書誌事項

タイトル別名

• The Mechanism Underlying the Synergetic Hypocholesterolemic Effect of Sesamin and .ALPHA.-Tocopherol in Rats Fed a High-Cholesterol Diet
• The mechanism underlying the synergetic hypocholesterolemic effect of sesamin and a tocopherol in rats fed a high cholesterol diet

抄録

Sesamin is a major lignan in sesame seed. We confirmed that ingestion of sesamin and α-tocopherol synergistically reduced the concentration of blood cholesterol in rats given a high-cholesterol diet. To elucidate the molecular mechanism behind this effect, we analyzed the gene-expression profiles in rat liver after co-ingestion of sesamin and α-tocopherol. Six-week-old male Sprague-Dawley rats were fed a 1% cholesterol diet (HC) or HC containing 0.2% sesamin, 1% α-tocopherol or sesamin + α-tocopherol for 10 days. Blood samples were collected on days 1, 3, 7, and 10 and livers were excised on day 10. The gene expressions of ATP-binding cassette, sub-family G (WHITE), members 5 (ABCG5) and 8 (ABCG8) were significantly increased, while the gene expression of apolipoprotein (Apo) A4 was significantly decreased. ABCG5 and ABCG8 form a functional heterodimer that acts as a cholesterol efflux transporter, which contributes to the excretion of cholesterol from the liver. ApoA4 controls the secretion of ApoB, which is a component of low-density-lipoprotein cholesterol. These studies indicate that the cholesterol-lowering mechanism underlying the effects of co-ingestion of sesamin and α-tocopherol might be attributable to increased biliary excretion of cholesterol and reduced ApoB secretion into the bloodstream.

収録刊行物

• Journal of Pharmacological Sciences

  Journal of Pharmacological Sciences 115 (3), 408-416, 2011

  公益社団法人 日本薬理学会

キーワード

• sesamin
• hypocholesterolemic activity
• <I>α</I>-tocopherol
• ATP-binding cassette transporter
• apolipoprotein

詳細情報

• CRID: 1390282680154767744
• NII論文ID: 10029892925
• NII書誌ID: AA11806667
• DOI: 10.1254/jphs.10287fp
• COI: 1:CAS:528:DC%2BC3MXktVOkt70%3D
• ISSN: 13478648
• ISSN: 13478613
• NDL書誌ID: 11010083
• PubMed: 21372506
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I11010083
• Web Site: https://search.jamas.or.jp/link/ui/2012013132
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可