Effect of Cigarette Smoke Components on Vascular Smooth Muscle Cell Migration Toward Platelet-Derived Growth Factor BB
-
- Yoshiyama Shinji
- Department of Molecular and Cellular Pharmacology, Gunma University Graduate School of Medicine, Japan
-
- Horinouchi Takahiro
- Department of Cellular Pharmacology, Hokkaido University Graduate School of Medicine, Japan
-
- Miwa Soichi
- Department of Cellular Pharmacology, Hokkaido University Graduate School of Medicine, Japan
-
- Wang Hong Hui
- Department of Molecular and Cellular Pharmacology, Gunma University Graduate School of Medicine, Japan
-
- Kohama Kazuhiro
- Department of Molecular and Cellular Pharmacology, Gunma University Graduate School of Medicine, Japan
-
- Nakamura Akio
- Department of Molecular and Cellular Pharmacology, Gunma University Graduate School of Medicine, Japan
Search this article
Abstract
Cigarette smoking is one of the factors causing accumulation of vascular smooth muscle cells (VSMCs) in atherosclerotic plaques. Changes in cell migration toward platelet-derived growth factor BB were investigated using a Boyden chamber after 48-h preincubation of GBaSM-4 VSMCs with nicotine or nicotine-free cigarette smoke extract (CSE). A nicotine concentration of 0.1 μM maximally promoted cell migration; 0.1% CSE also promoted cell migration, while high CSE concentrations damaged GBaSM-4 cells. Fetal bovine serum (FBS) long-depletion induced decrease in migration of GBaSM-4 cells. Our results suggest that nicotine and some CSE components can induce GBaSM-4 cell migration.
Journal
-
- Journal of Pharmacological Sciences
-
Journal of Pharmacological Sciences 115 (4), 532-535, 2011
The Japanese Pharmacological Society
- Tweet
Details 詳細情報について
-
- CRID
- 1390001205178587520
-
- NII Article ID
- 10029893589
-
- NII Book ID
- AA11806667
-
- COI
- 1:CAS:528:DC%2BC3MXls1GntLc%3D
-
- ISSN
- 13478648
- 13478613
-
- NDL BIB ID
- 11049352
-
- PubMed
- 21422730
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- Abstract License Flag
- Disallowed