Contribution of endothelium-derived hyperpolarizing factor in the regulation of vasoconstriction in peripheral resistance arteries

• Jin Xin

  Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan

• Satoh-Otonashi Yukiko

  Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan

• Zamami Yoshito

  Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan

• Takatori Shingo

  Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan

• Hashikawa-Hobara Narumi

  Department of Life Science, Okayama University of Science, Japan

• Kitamura Yoshihisa

  Department of Pharmaceutical Care and Health Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan

• Kawasaki Hiromu

  Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan

書誌事項

タイトル別名

• New Molecular Mechanisms for Cardiovascular Disease:Contribution of Endothelium-Derived Hyperpolarizing Factor in the Regulation of Vasoconstriction in Peripheral Resistance Arteries

抄録

Endothelium regulates vascular tone via release of endothelium-derived relaxing factors (EDRF) including nitric oxide (NO), prostaglandin I₂ (PGI₂), and endothelium-derived hyperpolarizing factor (EDHF). The mesenteric vascular bed produces vascular resistance to develop blood pressure and regulate tissue blood flow that plays an important role in maintenance of systemic blood pressure. There is now strong evidence that in these small resistance arteries, EDHF plays a major role in the response to vasoactive substances and regulation of vascular tone. Pharmacological analysis to investigate the role of the vascular endothelium in the regulation of α₁-adrenoceptor agonist (methoxamine)-induced vasoconstriction in rat mesenteric vascular beds showed that vasoconstriction induced by continuous perfusion of methoxamine (7 μM), but not high KCl (60 mM), time-dependently decreased to 20% of the initial constriction. The time-dependent reduction of methoxamine-induced vasoconstriction was inhibited by endothelium removal, inhibitor of EDHF (30 mM KCl, K⁺-channel blockers), and gap-junction inhibitor, but not NO synthase inhibitor and cyclooxygenase inhibitor and ageing. These results suggest that vascular endothelium counteracts to normalize excess vasoconstriction of the mesenteric resistance arteries by releasing EDHF, which is associated with activation of multiple K⁺-channels and gap junction involvement and markedly decreases with ageing.

収録刊行物

• Journal of Pharmacological Sciences

  Journal of Pharmacological Sciences 116 (4), 332-336, 2011

  公益社団法人 日本薬理学会

キーワード

• endothelium-derived hyperpolarizing factor
• endothelial regulation of vasoconstriction
• age
• rat mesenteric artery
• cardiovascular disease

詳細情報

• CRID: 1390001205178358912
• NII論文ID: 10029895441
• NII書誌ID: AA11806667
• DOI: 10.1254/jphs.10r30fm
• ISSN: 13478648
• ISSN: 13478613
• NDL書誌ID: 11206862
• PubMed: 21757845
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I11206862
• Web Site: https://search.jamas.or.jp/link/ui/2012183512
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可