A Novel Human Organic Anion Transporter NPT4 Mediates the Transport of Ochratoxin A
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- Jutabha Promsuk
- Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Japan
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- Anzai Naohiko
- Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Japan Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Japan
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- Hayashi Keitaro
- Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Japan
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- Domae Mariko
- Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Japan
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- Uchida Kohsuke
- Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Japan
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- Endou Hitoshi
- Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Japan
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- Sakurai Hiroyuki
- Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Japan
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抄録
In the present study, we investigated the transport of nephrotoxic mycotoxin ochratoxin A (OTxA) by a novel human organic anion transporter hNPT4 using the Xenopus oocyte expression system. hNPT4 mediated time- and concentration-dependent uptake of OTxA (Km: 802.8 μM) in a pH- and voltage-sensitive manner. Cis-inhibition experiments suggest that the substrate selectivity of hNPT4 is similar to that of hOAT4. The fact that the Km of OTxA for the efflux transporter hNPT4 was much higher than those for the uptake transporters hOAT1 and hOAT3 may favor the accumulation of OTxA in the tubular cell and lead to nephrotoxicity.
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 116 (4), 392-396, 2011
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205178367360
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- NII論文ID
- 10029895719
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- NII書誌ID
- AA11806667
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- ISSN
- 13478648
- 13478613
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- NDL書誌ID
- 11207025
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- PubMed
- 21778665
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可