Protective Effect of Neurotrophic Agent T-817MA Against Inner Ear Barotrauma in the Guinea Pig

• Maekawa Hitoshi

  Department of Otolaryngology, National Defense Medical College, Japan

• Matsunobu Takeshi

  Department of Otolaryngology, National Defense Medical College, Japan

• Satoh Yasushi

  Department of Anesthesiology, National Defense Medical College, Japan

• Kurioka Takaomi

  Department of Otolaryngology, National Defense Medical College, Japan

• Nakamura Asako

  Research Laboratories, Toyama Chemical Co., Ltd., Japan

• Iwakami Noboru

  Research Laboratories, Toyama Chemical Co., Ltd., Japan

• Shiotani Akihiro

  Department of Otolaryngology, National Defense Medical College, Japan

Abstract

T-817MA (1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}azetidin-3-ol maleate), a neurotrophic compound newly synthesized for the treatment of Alzheimer’s disease, has been found to reduce oxidative stress and exert neuroprotective effects. By assessing the auditory functioning and observing the cochlear sensory epithelia, we investigated whether T-817MA protects the cochlea from inner ear barotrauma in guinea pigs treated with rapidly intense pressure change. Sustained oral administration of T-817MA significantly reduced the extent of auditory threshold shifts and outer hair cell loss, indicating that T-817MA attenuates the intense pressure–induced cochlear damage that accompanies inner ear barotrauma via antioxidative activity.

Journal

• Journal of Pharmacological Sciences

  Journal of Pharmacological Sciences 117 (1), 67-70, 2011

  The Japanese Pharmacological Society

Keywords

• T-817MA
• inner ear barotrauma
• free radical

Details

• CRID: 1390282680155449600
• NII Article ID: 10029896029
• NII Book ID: AA11806667
• DOI: 10.1254/jphs.11033sc
• ISSN: 13478648
• ISSN: 13478613
• NDL BIB ID: 11243237
• Web Site: http://id.ndl.go.jp/bib/11243237
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I11243237
• Web Site: https://search.jamas.or.jp/link/ui/2012227836
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed