Comparison of Peripheral Neuropathy Induced by Standard and Nanoparticle Albumin-Bound Paclitaxel in Rats

• Yamashita Yuji

  Department of Pharmacy, Kyushu University Hospital, Japan

• Egashira Nobuaki

  Department of Pharmacy, Kyushu University Hospital, Japan

• Masuguchi Ken

  Department of Pharmacy, Kyushu University Hospital, Japan

• Ushio Soichiro

  Department of Pharmacy, Kyushu University Hospital, Japan

• Kawashiri Takehiro

  Department of Pharmacy, Kyushu University Hospital, Japan

• Oishi Ryozo

  Department of Pharmacy, Kyushu University Hospital, Japan

Abstract

Nanoparticle albumin–bound paclitaxel (nab-paclitaxel) is delivered to tumors and increases antitumor activity compared with solvent-based paclitaxel. However, in a clinical trial, higher and lower rates of peripheral neuropathy and neutropenia were observed. In this study, we compared the effects of nab-paclitaxel and standard paclitaxel on pain behaviors in rats. Repeated administration of nab-paclitaxel dose-dependently induced both mechanical and cold allodynia, and the effects of nab-paclitaxel on pain behaviors tended to be stronger than that of standard paclitaxel at the doses used clinically. These results suggest that closer attention must be paid to the neuropathy when administering nab-paclitaxel in clinical settings.

Journal

• Journal of Pharmacological Sciences

  Journal of Pharmacological Sciences 117 (2), 116-120, 2011

  The Japanese Pharmacological Society

Keywords

• nanoparticle albumin–bound paclitaxel
• paclitaxel
• peripheral neuropathy

Details

• CRID: 1390282680155113216
• NII Article ID: 10029896231
• NII Book ID: AA11806667
• DOI: 10.1254/jphs.11062sc
• ISSN: 13478648
• ISSN: 13478613
• NDL BIB ID: 11285994
• Web Site: http://id.ndl.go.jp/bib/11285994
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I11285994
• Web Site: https://search.jamas.or.jp/link/ui/2012272371
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed