Incremental Diagnostic Value of Regional Myocardial Blood Flow Quantification Over Relative Perfusion Imaging With Generator-Produced Rubidium-82 PET

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Author(s)

    • MANABE Osamu
    • Nuclear Medicine, Hokkaido University Graduate School of Medicine
    • KLEIN Ran
    • Nuclear Medicine, Hokkaido University Graduate School of Medicine
    • NAYA Masanao
    • Cardiovascular Medicine, Hokkaido University Graduate School of Medicine
    • YAMADA Shiro
    • Cardiovascular Medicine, Hokkaido University Graduate School of Medicine
    • DEKEMP Robert A.
    • National Cardiac PET Centre, Division of Cardiology, University of Ottawa Heart Institute
    • TSUTSUI Hiroyuki
    • Cardiovascular Medicine, Hokkaido University Graduate School of Medicine
    • TAMAKI Nagara
    • Nuclear Medicine, Hokkaido University Graduate School of Medicine

Abstract

<b><i>Background:</i></b> Myocardial blood flow (MBF) can be measured with positron emission tomography (PET) and its quantification should provide diagnostic information beyond that obtained through standard visual analysis. However, this possibility has not been fully studied with PET and generator-produced rubidium-82 (<sup>82</sup>Rb). We evaluated regional MBF in segments with and without ischemia using <sup>82</sup>Rb PET in patients with coronary artery disease (CAD). <b><i>Methods and Results:</i></b> Rest and stress <sup>82</sup>Rb PET and coronary angiography were performed for 12 patients with CAD. Based on angiography and relative <sup>82</sup>Rb perfusion images, segments were classified into 4 groups (Group A: myocardial ischemia with >70% diameter stenosis; Group B: no ischemia with stenosis; Group C: no ischemia without stenosis; Group D: ischemia without stenosis). Rest MBF was similar among the 4 groups. Groups A and B showed reduced hyperemic MBF compared with Group C (P<0.05 vs. Group C) [Group A (n=16) 1.28±0.58ml·min<sup>-1</sup>·g<sup>-1</sup>; Group B (n=11) 1.72±0.64ml·min<sup>-1</sup>·g<sup>-1</sup>; Group C (n=9) 2.60±1.09ml·min<sup>-1</sup>·g<sup>-1</sup>; Group D (n=2) 2.33ml·min<sup>-1</sup>·g<sup>-1</sup>]. Coronary flow reserves were inversely correlated with percent diameter stenosis (r=0.76, P<0.0001). <b><i>Conclusions:</i></b> Segments with ischemia and coronary stenosis had reduced hyperemic MBF. Segments with coronary stenosis without ischemia also had reduced hyperemic MBF compared with non-stenotic segments. MBF quantification using <sup>82</sup>Rb PET may provide additional diagnostic information. (<i>Circ J</i> 2011; <b>75:</b> 2628-2634)<br>

Journal

  • Circulation Journal

    Circulation Journal 75(11), 2628-2634, 2011-10-25

    The Japanese Circulation Society

References:  39

Cited by:  1

Codes

  • NII Article ID (NAID)
    10030032283
  • NII NACSIS-CAT ID (NCID)
    AA11591968
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    13469843
  • Data Source
    CJP  CJPref  J-STAGE 
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