Comparison of selenoneine found in marine organisms with selenite in the interaction with mercury compounds in vitro
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- Anan Yasumi
- Laboratory of Chemical Toxicology and Environmental Health, Showa Pharmaceutical University
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- Tanabe Shinsuke
- Center for Marine Environmental Studies (CMES), Ehime University
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- Ogra Yasumitsu
- Laboratory of Chemical Toxicology and Environmental Health, Showa Pharmaceutical University High Technology Research Center, Showa Pharmaceutical University
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Abstract
Selenium (Se) is an essential micronutrient because it forms the active center of selenoenzymes/selenoproteins in the form of selenocysteine. Another biological significance of Se is that it detoxifies inorganic mercury (iHg) by directly interacting with it. Recently, a novel selenometabolite, selenoneine (2-selenyl-N,N,N-trimethyl-L-histidine), was identified in several marine animals. However, its biological significance is still unclear. In this study, the ability of selenoneine to form a complex with iHg and methyl Hg (MeHg) was evaluated in vitro. Whereas selenite serving as the positive control reacted with iHg by direct interaction after being converted into selenide by endogenous reductants, such as glutathione (GSH), selenoneine did not interact with iHg or MeHg in the liver homogenate of marine turtle. This indicates that selenoneine may not play a role in the detoxification of Hg.
Journal
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- The Journal of Toxicological Sciences
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The Journal of Toxicological Sciences 36 (6), 725-731, 2011
The Japanese Society of Toxicology
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Details 詳細情報について
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- CRID
- 1390001204902570368
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- NII Article ID
- 10030036704
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- NII Book ID
- AN00002808
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- ISSN
- 18803989
- 03881350
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- NDL BIB ID
- 023358457
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed