A Case of Neuroendcrine Tumor of the Ileum with Liver Metastases Treated with Transcatheter Arterial Chemoembolization with Degradable Starch Microspheres and Biotherapy with Octreotide

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  • OONO Takashi
    Department of Gastroenterology and Hepatology (Internal Medicine I.), Yamaguchi University Graduate School of Medicine
  • SEGAWA Makoto
    Department of Community Health and Medicine, Yamaguchi University School of Medicine
  • HASHIMOTO Shinichi
    Department of Gastroenterology and Hepatology (Internal Medicine I.), Yamaguchi University Graduate School of Medicine
  • UCHIDA Koichi
    Department of Gastroenterology and Hepatology (Internal Medicine I.), Yamaguchi University Graduate School of Medicine
  • TERAI Shuji
    Department of Gastroenterology and Hepatology (Internal Medicine I.), Yamaguchi University Graduate School of Medicine
  • YAMASAKI Takahiro
    Department of Gastroenterological Endoscopy, Yamaguchi University Hospital
  • HOSHII Yoshinobu
    Department of Surgical Pathology, Yamaguchi University Hospital
  • SAKAIDA Isao
    Department of Gastroenterology and Hepatology (Internal Medicine I.), Yamaguchi University Graduate School of Medicine

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Other Title
  • 多発性肝転移に対し，Degradable starch microspheres（DSM）とリピオドールによる肝動脈化学塞栓療法を施行後，オクトレオチド酢酸塩を継続投与した回腸原発神経内分泌腫瘍肝転移の一例
  • タハツセイ カン テンイ ニ タイシ Degradable starch microspheres DSM ト リピオドール ニヨル カンドウミャク カガク ソクセン リョウホウ オ シコウゴ オクトレオチド サクサンエン オ ケイゾク トウヨ シタ カイチョウ ゲンパツ シンケイ ナイブンピツ シュヨウ カン テンイ ノ イチレイ
  • 症例報告 多発性肝転移に対し, Degradable starch microspheres (DSM)と リピオドールによる肝動脈化学塞栓療法を施行後, オクドレオチド酢酸塩を継続投与した回腸原発神経内分泌腫瘍肝転移の一例
  • ショウレイ ホウコク タハツセイ ギモ テンイ ニ タイシ, Degradable starch microspheres (DSM)ト リピオドール ニ ヨル キモ ドウミャク カガク ソクセン リョウホウ オ シコウ ゴ, オクドレオチド サクサンエン オ ケイゾク トウヨ シタ カイチョウ ゲンパツ シンケイ ナイブンピツ シュヨウ ギモ テンイ ノ イチレイ

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Abstract

We report a case of neuroendocrine tumor of the ileum with liver metastases. A 50 year-old level woman was pointed out multiple liver tumors by the abdominal ultrasonography and admitted to our hospital. Histological diagnosis was neuroendocrine tumor G1 (WHO classification) on tumor biopsy of the liver. Multiple ileum tumors were found on endoscopic examination of the ileum using double balloon endoscopy and assessed as a primary lesion. Transcatheter arterial infusion chemotherapy using iodized oil (lipiodol) and degradable starch microspheres (Lip-TAI using DSM) was performed for the metastatic lesion of the liver, and tumor regression was observed. Long-acting somatostatin analogue (octreotide) was administered once a month as an additional therapy. Inhibition of the tumor proliferation in both primary and metastatic lesion was observed for about 2 years. Combination therapy with Lip-TAI using DSM and biotherapy with octreotide will be a promising therapy for unresectable neuroendocrine tumor with liver metastases.

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