Spatial learning and memory deficit of low level polybrominated diphenyl ethers-47 in male adult rat is modulated by intracellular glutamate receptors

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著者

    • Tang Yan TANG Yan
    • Department of Occupational and Environmental Medicine, School of Public Health, Luzhou Medical College
    • Li Xiang LI Xiang
    • Department of Occupational and Environmental Medicine, School of Public Health, Luzhou Medical College
    • CHEN Chengzhi
    • Department of Occupational and Environmental Medicine, School of Public Health, Chongqing Medical University
    • QI Youbin
    • Department of Occupational and Environmental Medicine, School of Public Health, Chongqing Medical University
    • YU Xuelan
    • Department of Occupational and Environmental Medicine, School of Public Health, Luzhou Medical College
    • LIU Yang
    • Department of Occupational and Environmental Medicine, School of Public Health, Luzhou Medical College
    • PENG Changyan
    • Department of Occupational and Environmental Medicine, School of Public Health, Luzhou Medical College
    • CHEN Hui
    • Department of Occupational and Environmental Medicine, School of Public Health, Luzhou Medical College

抄録

Polybrominated diphenyl ethers (PBDEs), a class of widely used flame retardants, are extensively diffused in the environment. Of particular concern are the reported highly sensitivity of PBDEs in children or developmental animals, however, almost no information is available on their potential effects on adults and the mechanisms are still unknown. In the present study, we investigated the neurotoxic effects of sub-chronic PBDE-47 exposure on adult male Sprague-Dawley rats. Thus, PBDE-47, 0.1, 0.5 and 1 mg/kg per day was administered to rats by gavage for 30 days. The learning and memory function was tested by Morris water maze. Further, in order to explore the potential mechanism, the expression of NMDA-receptors was evaluated by using both immunohistochemistry (IHC) and RT-PCR. Our results showed that sub-chronic exposure to PBDE-47 produced learning and memory deficits in male adult rats. Also, significant decrease in the CA1, CA3 and dentate gyrus areas of hippocampus affected by all three doses of PBDE-47 on the expression of NR<sub>1</sub>,<sub> </sub>NR<sub>2</sub>B and Glu were found by IHC. In addition, the evaluation of expression of the NR<sub>1</sub>, NR<sub>2</sub>B and NR<sub>2</sub>C showed statistically significant decrease in mRNA expression in rats exposed to PBDE-47. These findings showed that sub-chronic exposure to PBDE-47 could also induce behavioral alterations and the neurotoxic effects might due to the down-regulation expression of NMDA receptors. Our data indicated that the possibility of exposure of adults to PBDE-47 warranted further studies to characterize their potential neurotoxicity.

収録刊行物

  • Journal of toxicological sciences

    Journal of toxicological sciences 37(2), 223-233, 2012-04-01

    一般社団法人 日本毒性学会

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各種コード

  • NII論文ID(NAID)
    10030126421
  • NII書誌ID(NCID)
    AN00002808
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    03881350
  • NDL 記事登録ID
    023673798
  • NDL 請求記号
    Z19-1022
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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