Topical treatment of oral cavity and wounded skin with a new disinfection system utilizing photolysis of hydrogen peroxide in rats

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The present study aimed to evaluate the acute locally injurious property of hydroxyl radical generation system by photolysis of H<sub>2</sub>O<sub>2</sub>, which is a new disinfection system for the treatment of periodontitis developed in our laboratory. Firstly, generation of the hydroxyl radical by a test device utilizing the photolysis of H<sub>2</sub>O<sub>2</sub> was confirmed by applying an electron spin resonance (ESR)-spin trapping technique. Secondly, the bactericidal effect of the device was examined under a simulant condition in which <i>Staphylococcus aureus</i> suspended in 1 M H<sub>2</sub>O<sub>2</sub> was irradiated with laser light emitted from the test device, resulting in substantial reduction of the colony forming unit of the bacteria within a short time as 2 min. Finally, acute topical effect of the disinfection system on rat oral mucosa and wounded skin was evaluated by histological examination. No abnormal findings were observed in the buccal mucosal region treated three times with 1 M H<sub>2</sub>O<sub>2</sub> and irradiation. Similarly, no abnormal findings were observed during the healing of skin treated with 1 M H<sub>2</sub>O<sub>2</sub> and irradiation immediately after wounding. Since topical treatment with the novel disinfection technique utilizing the photolysis of H<sub>2</sub>O<sub>2</sub> had no detrimental effect on the oral mucosa and the healing of full thickness skin wounds in rats, it is expected that the acute locally injurious property of the disinfection technique is low.

収録刊行物

  • Journal of toxicological sciences

    Journal of toxicological sciences 37(2), 329-335, 2012-04-01

    一般社団法人 日本毒性学会

参考文献:  22件中 1-22件 を表示

被引用文献:  3件中 1-3件 を表示

各種コード

  • NII論文ID(NAID)
    10030126757
  • NII書誌ID(NCID)
    AN00002808
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    03881350
  • NDL 記事登録ID
    023674474
  • NDL 請求記号
    Z19-1022
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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