Topical treatment of oral cavity and wounded skin with a new disinfection system utilizing photolysis of hydrogen peroxide in rats
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- Yamada Yasutomo
- Tohoku University Graduate School of Dentistry
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- Mokudai Takayuki
- Tohoku University Graduate School of Dentistry
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- Nakamura Keisuke
- Tohoku University Graduate School of Dentistry
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- Hayashi Eisei
- Tohoku University Graduate School of Dentistry
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- Kawana Yoshiko
- AZ Co., Ltd.
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- Kanno Taro
- Tohoku University Graduate School of Dentistry
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- Sasaki Keiichi
- Tohoku University Graduate School of Dentistry
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- Niwano Yoshimi
- Tohoku University Graduate School of Dentistry
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抄録
The present study aimed to evaluate the acute locally injurious property of hydroxyl radical generation system by photolysis of H2O2, which is a new disinfection system for the treatment of periodontitis developed in our laboratory. Firstly, generation of the hydroxyl radical by a test device utilizing the photolysis of H2O2 was confirmed by applying an electron spin resonance (ESR)-spin trapping technique. Secondly, the bactericidal effect of the device was examined under a simulant condition in which Staphylococcus aureus suspended in 1 M H2O2 was irradiated with laser light emitted from the test device, resulting in substantial reduction of the colony forming unit of the bacteria within a short time as 2 min. Finally, acute topical effect of the disinfection system on rat oral mucosa and wounded skin was evaluated by histological examination. No abnormal findings were observed in the buccal mucosal region treated three times with 1 M H2O2 and irradiation. Similarly, no abnormal findings were observed during the healing of skin treated with 1 M H2O2 and irradiation immediately after wounding. Since topical treatment with the novel disinfection technique utilizing the photolysis of H2O2 had no detrimental effect on the oral mucosa and the healing of full thickness skin wounds in rats, it is expected that the acute locally injurious property of the disinfection technique is low.
収録刊行物
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- The Journal of Toxicological Sciences
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The Journal of Toxicological Sciences 37 (5), 1091-1091, 2012
一般社団法人 日本毒性学会
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詳細情報 詳細情報について
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- CRID
- 1390001204905684736
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- NII論文ID
- 130004447000
- 10030126757
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- NII書誌ID
- AN00002808
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- COI
- 1:STN:280:DC%2BC3s%2Fis1Omug%3D%3D
- 1:CAS:528:DC%2BC38XotVyltb4%3D
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- ISSN
- 18803989
- 03881350
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- NDL書誌ID
- 023674474
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- PubMed
- 22467023
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可