Enhancing effects of trichloroethylene and tetrachloroethylene on type I allergic responses in mice

• Seo Makoto

  Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University Department of Biochemistry, Faculty of Medicine, Saitama Medical University

• Kobayashi Ryo

  Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University

• Okamura Tetsunori

  Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University

• Ikeda Koji

  Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University

• Satoh Masahiko

  Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University

• Inagaki Naoki

  Laboratory of Pharmacology, Gifu Pharmaceutical University

• Nagai Hiroichi

  Laboratory of Pharmacology, Gifu Pharmaceutical University

• Nagase Hisamitsu

  Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University

抄録

Trichloroethylene (TCE) and tetrachloroethylene (perchloroethylene; PCE) are commonly identified as environmental contaminants of groundwater. Previously, we investigated the enhancing effects of TCE and PCE on antigen-induced histamine release and inflammatory mediator production in rat mast cells. In this study, to examine the potential effect of TCE and PCE on antigen-induced histamine release from mouse mast cells, mouse bone marrow-derived mast cells (BMMC) were sensitized with anti-dinitrophenol (DNP) monoclonal IgE antibody and then stimulated with DNP-BSA containing with TCE or PCE. Both TCE and PCE significantly enhanced antigen-induced histamine release from BMMC. Next we investigated the effects of TCE and PCE on the passive cutaneous anaphylaxis (PCA) reaction in vivo using ICR mice. TCE and PCE significantly enhanced the PCA reaction in a dose-dependent manner. In addition, we examined the enhancing effects of ingesting small amount of TCE and PCE in drinking water on antigen-stimulated allergic responses. After the ICR mice had ingested TCE or PCE in their drinking water for 2 or 4 weeks, we performed the PCA reaction. Both TCE and PCE ingestion enhanced the PCA reaction in a dose-dependent manner for 4 weeks. These results suggest that exposure to TCE and PCE leads to the augmentation of type I allergic responses in many species.

収録刊行物

• Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ

  Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ 37 (2), 439-445, 2012

  一般社団法人　日本毒性学会

キーワード

• Trichloroethylene
• Tetrachloroethylene
• BMMC
• Histamine release
• PCA reaction

詳細情報

• CRID: 1390282679880394624
• NII論文ID: 10030127130
• NII書誌ID: AN00002808
• DOI: 10.2131/jts.37.439
• COI: 1:CAS:528:DC%2BC38XotVylurw%3D
• ISSN: 18803989
• ISSN: 03881350
• NDL書誌ID: 023674869
• PubMed: 22467035
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I023674869
• Web Site: https://www.jstage.jst.go.jp/article/jts/37/2/37_2_439/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2013000659
• 本文言語コード: en
• データソース種別:
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  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
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