Diffusion Tensor Imaging of Idiopathic Normal Pressure Hydrocephalus : A Voxel-Based Fractional Anisotropy Study

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著者

    • KOYAMA Tetsuo
    • Department of Rehabilitation Medicine, Nishinomiya Kyoritsu Neurosurgical Hospital
    • MARUMOTO Kohei
    • Department of Physical Medicine and Rehabilitation, Hyogo College of Medicine
    • DOMEN Kazuhisa
    • Department of Physical Medicine and Rehabilitation, Hyogo College of Medicine
    • OHMURA Takehisa
    • Department of Neurosurgery, Nishinomiya Kyoritsu Neurosurgical Hospital
    • MIYAKE Hiroji
    • Department of Neurosurgery, Nishinomiya Kyoritsu Neurosurgical Hospital

抄録

Diffusion tensor imaging (DTI) using a 3.0 tesla magnetic resonance scanner was used to investigate white matter changes caused by idiopathic normal pressure hydrocephalus (INPH) in 10 patients diagnosed by clinical symptoms (gait disturbance, dementia, and/or urinary incontinence) and Evans index >0.3, and compared with findings for 10 age-matched controls (≥60 years). Then, using a computer-automated method, fractional anisotropy (FA) brain maps were generated and finally transformed into the standard space. Voxel-based FA values within two regions of interests (ROIs), the forceps minor and corticospinal tracts, were then separately evaluated. Within each ROI, statistical comparisons of results from the INPH and control groups were performed. In addition, for INPH patients, grading scores for clinical symptoms and FA values were correlated. The forceps minor mean FA value was much smaller for the INPH group (0.504) than for the control group (0.631). The corticospinal tract mean FA value was slightly smaller for the INPH group (0.588) than for the control group (0.632). Additional analyses indicated that lower FA values within the forceps minor tended to be associated with clinical symptoms such as urinary incontinence and gait disturbance. Our findings indicate FA values decreased in the forceps minor of INPH patients. We also found that lower values were associated with severer clinical symptoms, implying that DTI techniques may be developed for more accurate diagnosis.<br>

収録刊行物

  • Neurologia medico-chirurgica = 神経外科

    Neurologia medico-chirurgica = 神経外科 52(2), 68-74, 2012-02-15

    The Japan Neurosurgical Society

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各種コード

  • NII論文ID(NAID)
    10030127267
  • NII書誌ID(NCID)
    AN00358613
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    04708105
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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