Glioma Immunotherapy With Combined Autologous Tumor Cell and Endothelial Cell Vaccine In Vivo

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著者

    • SAKAMOTO Noriaki
    • Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba
    • UEMAE Youji
    • Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba
    • ISHIKAWA Eiichi
    • Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba
    • TAKANO Shingo
    • Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba
    • NAKAI Kei
    • Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba
    • YAMAMOTO Tetsuya
    • Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba
    • ZABORONOK Alexander
    • Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba
    • MATSUMURA Akira
    • Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba

抄録

Combined vaccines containing GL261 murine glioma cells and F-2 murine endothelial cells fixed with glutaraldehyde-phosphate buffered saline were injected into the intradermal tissue of the tail base of C57BL/6 mice. After the vaccination, GL261 cells were injected subcutaneously into the left flank of the mice. Vaccination with fixed F-2 cells induced the development of relatively high amounts of interferon-gamma-releasing cells after in vitro re-stimulation with vascular endothelial growth factor-receptor 2 peptide. Tumor growth was inhibited after preventive use of the combined vaccine, prepared from GL261 and F-2 cells. Tumor specimens obtained from the combined vaccine group in a therapeutic experiment showed significantly decreased vessel count. Glioma immunotherapy with a combined vaccine prepared from tumor cells and endothelial cells might represent a new clinical strategy, as such combinations may theoretically affect both high-grade glioma cells and their environment.<br>

収録刊行物

  • Neurologia medico-chirurgica = 神経外科

    Neurologia medico-chirurgica = 神経外科 52(4), 194-201, 2012-04-15

    The Japan Neurosurgical Society

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各種コード

  • NII論文ID(NAID)
    10030127755
  • NII書誌ID(NCID)
    AN00358613
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    04708105
  • データ提供元
    CJP書誌  J-STAGE 
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