The biomimetic apatite-cefalotin coatings on modified titanium

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著者

    • KANG Min-Kyung
    • BK21, Department and Research Institute of Dental Biomaterials and Bioengineering, and Research Center for Orofacial Hard Tissue Regeneration, College of Dentistry, Yonsei University
    • LEE Sang-Bae
    • BK21, Department and Research Institute of Dental Biomaterials and Bioengineering, and Research Center for Orofacial Hard Tissue Regeneration, College of Dentistry, Yonsei University
    • MOON Seung-Kyun
    • BK21, Department and Research Institute of Dental Biomaterials and Bioengineering, and Research Center for Orofacial Hard Tissue Regeneration, College of Dentistry, Yonsei University
    • KIM Kwang-Mahn
    • BK21, Department and Research Institute of Dental Biomaterials and Bioengineering, and Research Center for Orofacial Hard Tissue Regeneration, College of Dentistry, Yonsei University
    • KIM Kyoung-Nam
    • BK21, Department and Research Institute of Dental Biomaterials and Bioengineering, and Research Center for Orofacial Hard Tissue Regeneration, College of Dentistry, Yonsei University

抄録

Dental implant failure often occurs due to oral bacterial infection. The aim of this study was to demonstrate that antibiotic efficacy could be enhanced with modified titanium. First, the titanium was modified by anodization and heat-treatment. Then, a biomimetic coating process was completed in two steps. Surface characterization was performed with scanning electron microscopy, energy dispersive spectroscopy, and X-ray diffraction. Release of antibiotic was evaluated by UV/VIS spectrometry, and the antibacterial effect was evaluated on <I>Streptococcus mutans</I>. After the second coating step, we observed a thick homogeneous apatite layer that contained the antibiotic, cefalotin. The titanium formed a rutile phase after the heat treatment, and a carbonated apatite phase appeared after biomimetic coating. We found that the modified titanium increased the loading of cefalotin onto the hydroxyapatite coated surface. The results suggested that modified titanium coated with a cefalotin using biomimetic coating method might be useful for preventing local post-surgical implant infections.

収録刊行物

  • Dental materials journal

    Dental materials journal 31(1), 98-105, 2012-01-01

    The Japanese Society for Dental Materials and Devices

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各種コード

  • NII論文ID(NAID)
    10030128384
  • NII書誌ID(NCID)
    AA10443149
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    02874547
  • データ提供元
    CJP書誌  J-STAGE 
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