Association of Heart Rate Variability With Arrhythmic Events in Patients With Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia

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著者

    • BATTIPAGLIA Irma
    • Department of Cardiovascular Medicine, Cardiology Center, Catholic University of the Sacred Heart
    • SCALONE Giancarla
    • Department of Cardiovascular Medicine, Cardiology Center, Catholic University of the Sacred Heart
    • MACCHIONE Andrea
    • Department of Cardiovascular Medicine, Cardiology Center, Catholic University of the Sacred Heart
    • PINNACCHIO Gaetano
    • Department of Cardiovascular Medicine, Cardiology Center, Catholic University of the Sacred Heart
    • LAURITO Marianna
    • Department of Cardiovascular Medicine, Cardiology Center, Catholic University of the Sacred Heart
    • MILO Maria
    • Department of Cardiovascular Medicine, Cardiology Center, Catholic University of the Sacred Heart
    • PELARGONIO Gemma
    • Department of Cardiovascular Medicine, Cardiology Center, Catholic University of the Sacred Heart
    • BENCARDINO Gianluigi
    • Department of Cardiovascular Medicine, Cardiology Center, Catholic University of the Sacred Heart
    • BELLOCCI Fulvio
    • Department of Cardiovascular Medicine, Cardiology Center, Catholic University of the Sacred Heart
    • PIERONI Maurizio
    • Department of Cardiovascular Medicine, Cardiology Center, Catholic University of the Sacred Heart
    • LANZA Gaetano A.
    • Department of Cardiovascular Medicine, Cardiology Center, Catholic University of the Sacred Heart
    • CREA Filippo
    • Department of Cardiovascular Medicine, Cardiology Center, Catholic University of the Sacred Heart

抄録

<b><i>Background:</i></b> Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is associated with an increased risk of sudden cardiac death (SCD). Risk stratification of ARVC/D patients, however, remains an unresolved issue. In this study we investigated whether heart rate variability (HRV) can be helpful in identifying ARVC/D patients with increased risk of arrhythmic events. <b><i>Methods and Results:</i></b> We studied 30 consecutive patients (17 males; 45.4±18 years) with ARVC/D, diagnosed according to guideline criteria; 15 patients (50%) had received an implantable cardioverter defibrillator (ICD) for primary SCD prevention. HRV was assessed on 24-h ECG Holter monitoring. The primary endpoint was the occurrence of major arrhythmic events (SCD, sustained ventricular tachycardia (VT), ICD therapy for sustained VT or ventricular fibrillation (VF)). During the follow-up period (19±7 months), no deaths occurred, but 5 patients (17%) experienced arrhythmic events (4 VTs and 1 VF, all in the ICD group). All HRV parameters were significantly lower in patients with, compared with those without, arrhythmic events. Low-frequency amplitude was the most significant HRV variable associated with arrhythmic events in univariate Cox regression analysis (P=0.017), and was the only significant predictor of arrhythmic events in multivariable regression analysis (hazard ratio 0.88, P=0.047), together with unexplained syncope (hazard ratio 16.1, P=0.039). <b><i>Conclusions:</i></b> Our data show that among ARVC/D patients HRV analysis might be helpful in identifying those with increased risk of major arrhythmic events. (<i>Circ J</i> 2012; <b>76:</b> 618-623)<br>

収録刊行物

  • Circulation journal : official journal of the Japanese Circulation Society

    Circulation journal : official journal of the Japanese Circulation Society 76(3), 618-623, 2012-02-25

    The Japanese Circulation Society

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各種コード

  • NII論文ID(NAID)
    10030129852
  • NII書誌ID(NCID)
    AA11591968
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13469843
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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