Impact of Left Ventricular Afterload on Longitudinal Dyssynchrony in Patients With Severe Aortic Stenosis and Preserved Ejection Fraction

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著者

    • YAMAWAKI Kohei
    • Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
    • TANAKA Hidekazu
    • Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
    • MATSUMOTO Kensuke
    • Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
    • HIRAISHI Mana
    • Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
    • MIYOSHI Tatsuya
    • Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
    • KANEKO Akihiro
    • Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
    • TSUJI Takayuki
    • Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
    • RYO Keiko
    • Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
    • NORISADA Kazuko
    • Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
    • FUKUDA Yuko
    • Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
    • TATSUMI Kazuhiro
    • Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
    • ONISHI Tetsuari
    • Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
    • OKADA Kenji
    • Division of Cardiovascular Surgery Department of Surgery, Kobe University Graduate School of Medicine
    • OKITA Yutaka
    • Division of Cardiovascular Surgery Department of Surgery, Kobe University Graduate School of Medicine
    • KAWAI Hiroya
    • Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
    • HIRATA Ken-ichi
    • Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine

抄録

<b><i>Background:</i></b> The purpose of this study was to investigate whether patients with severe aortic stenosis (AS) and preserved ejection fraction (EF) have dyssynchrony and whether it improves after aortic valve replacement (AVR). <b><i>Methods and Results:</i></b> We studied 30 consecutive patients with severe AS and preserved EF undergoing AVR. For baseline comparison, we studied 17 EF-matched patients with mild-to-moderate AS, and 18 EF-matched normal volunteers. Longitudinal dyssynchrony was determined as the standard deviation for time-to-peak speckle-tracking strain in apical 4- and 2-chamber views at the basal- and mid-levels. Radial and circumferential dyssynchrony was determined as the difference for time-to-peak strain between the anteroseptum and posterior wall from the mid-left ventricular (LV) short-axis view. Each of the myocardial functions was also evaluated by averaging each peak systolic strain. Longitudinal dyssynchrony and function in patients with severe AS was significantly worse than in the patients with mild-to-moderate AS and the controls (94±46 vs. 66±18ms* and 52±17ms*, and 12.5±3.7% vs. 16±3.5%* and 18.7±3.7%*, respectively, *P<0.05, vs. severe AS). In contrast, radial and circumferential dyssynchrony were similar for the 3 groups. Importantly, the dyssynchrony of patients with severe AS significantly improved after AVR from 94±46ms to 68±22ms (P<0.005). <b><i>Conclusions:</i></b> Significant longitudinal dyssynchrony was present in patients with severe AS and preserved EF, and it improved after AVR. (<i>Circ J</i> 2012; <b>76:</b> 744-751)<br>

収録刊行物

  • Circulation journal : official journal of the Japanese Circulation Society

    Circulation journal : official journal of the Japanese Circulation Society 76(3), 744-751, 2012-02-25

    一般社団法人 日本循環器学会

参考文献:  28件中 1-28件 を表示

被引用文献:  3件中 1-3件 を表示

各種コード

  • NII論文ID(NAID)
    10030130472
  • NII書誌ID(NCID)
    AA11591968
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13469843
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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