Effects of Valsartan on Fibrinolysis in Hypertensive Patients With Metabolic Syndrome
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- Miyata Masaaki
- Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University
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- Ikeda Yoshiyuki
- Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University
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- Nakamura Shuji
- Heiwadai Memorial Hospital Heiwadai Memorial Hospital
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- Sasaki Takeshi
- Makurazaki City Hospital Makurazaki City Hospital
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- Abe Satoshi
- Tarumizu Central Hospital Tarumizu Central Hospital
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- Minagoe Shinichi
- Kagoshima Medical Center Kagoshima Medical Center
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- Torii Hiroyuki
- Kagoshima Medical Association Hospital Kagoshima Medical Association Hospital
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- Lee Souki
- Kagoshima City Hospital Kagoshima City Hospital
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- Tateishi Shigeki
- Akune Citizen Hospital Akune Citizen Hospital
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- Kihara Koichi
- Fujimoto Hayasuzu Hospital Fujimoto Hayasuzu Hospital
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- Ohba Ichiro
- Imakiire General Hospital Imakiire General Hospital
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- Kajiya Shoko
- Uenomachi-Kajiya Clinic Uenomachi-Kajiya Clinic
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- Furusho Yuko
- Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University
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- Hamasaki Shuichi
- Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University
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- Tei Chuwa
- Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University
書誌事項
- タイトル別名
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- – The KACT-MetS Study –
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Background: The purpose of this study was to analyze the effect of valsartan on abnormal adipocyte metabolism and prothrombotic state in hypertensive patients with metabolic syndrome (MetS). Methods and Results: We conducted a multicenter, prospective, randomized, parallel-group controlled trial in 150 hypertensive patients with MetS. They were randomly assigned to receive either 80-160mg valsartan per day (valsartan group, n=79) or other conventional treatment without a renin-angiotensin system (RAS) inhibitor (non-RAS inhibitor group, n=71). After 1 year, there were no significant differences between the 2 groups in the changes in systolic and diastolic blood pressures (valsartan: 153±15/86±15 to 138±16/77±12mmHg; non-RAS inhibitor: 150±14/82±15 to 137±15/76±10mmHg). There was a significant difference in the change in the levels of plasminogen activator inhibitor-1 (PAI-1) between the 2 groups after 1 year (valsartan: 3.7±3.2ng/ml; non-RAS inhibitor: 5.8±3.3ng/ml, P=0.04). There was no significant difference between groups in the change in the concentration of adiponectin after 1 year (valsartan: 0.3±0.4μg/ml; non-RAS inhibitor: 0.9±0.4μg/ml, P=0.22). The animal study showed aortic PAI-1 protein expression was reduced in double knockout mice of angiotensin II type 1a receptor and apolipoprotein E (apoE) compared with the apoE knockout mice. Conclusions: Valsartan reduced plasma PAI-1 levels compared to non-RAS inhibitor in hypertensive patients with MetS, which suggests it may be useful for improving fibrinolytic function. (Circ J 2012; 76: 843-851)<br>
収録刊行物
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- Circulation Journal
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Circulation Journal 76 (4), 843-851, 2012
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390282680079579136
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- NII論文ID
- 10030131024
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- NII書誌ID
- AA11591968
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- COI
- 1:CAS:528:DC%2BC38XmsFejurs%3D
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- ISSN
- 13474820
- 13469843
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- PubMed
- 22451451
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- 本文言語コード
- en
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- データソース種別
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- JaLC
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- PubMed
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