Effects of Remote Ischemic Preconditioning With Postconditioning in Patients Undergoing Off-Pump Coronary Artery Bypass Surgery : Randomized Controlled Trial

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著者

    • HONG Deok Man
    • Department of Anesthesiology and Pain Medicine, Seoul National University Hospital
    • JEON Yunseok
    • Department of Anesthesiology and Pain Medicine, Seoul National University Hospital
    • LEE Chang-Soon
    • Department of Anesthesiology and Pain Medicine, Seoul National University Hospital
    • KIM Hyun Joo
    • Department of Anesthesiology and Pain Medicine, Seoul National University Hospital
    • LEE Jung-Man
    • Department of Anesthesiology and Pain Medicine, Seoul National University Hospital
    • BAHK Jae-Hyon
    • Department of Anesthesiology and Pain Medicine, Seoul National University Hospital
    • KIM Ki-Bong
    • Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital
    • HWANG Ho Young
    • Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital

抄録

<b><i>Background:</i></b> Myocardial injury is associated with an adverse outcome after off-pump coronary artery bypass graft surgery (OPCAB). The authors conducted a randomized controlled trial to evaluate whether remote ischemic preconditioning (RIPC) with remote ischemic postconditioning (RIPostC) reduces myocardial injury in patients undergoing OPCAB. <b><i>Methods and Results:</i></b> Seventy patients scheduled for OPCAB were randomly assigned to an RIPC+RIPostC group (n=35) or a control group (n=35). In the RIPC+RIPostC group, 4 cycles of 5-min ischemia and 5-min reperfusion were done on a lower limb before anastomoses (RIPC) and after anastomoses (RIPostC). RIPC+RIPostC significantly reduced postoperative serum troponin I levels (P=0.001). The area under the curve for postoperative troponin I was 48.7% lower in the RIPC+RIPostC group (median [interquartile range], 21.3h·ng<sup>-1</sup>·ml<sup>-1</sup>, 16.5-53.1h·ng<sup>-1</sup>·ml<sup>-1</sup> vs. 41.5h·ng<sup>-1</sup>·ml<sup>-1</sup>, 24.6-90.2h·ng<sup>-1</sup>·ml<sup>-1</sup>, P=0.020). There was no significant difference in creatinine levels and PaO<sub>2</sub>/F<sub>i</sub>O<sub>2</sub> ratios between the 2 groups. <b><i>Conclusions:</i></b> RIPC+RIPostC by lower limb ischemia decreased postoperative myocardial enzyme elevation by almost half postoperatively in patients undergoing OPCAB. (<i>Circ J</i> 2012; <b>76:</b> 884-890)<br>

収録刊行物

  • Circulation journal : official journal of the Japanese Circulation Society

    Circulation journal : official journal of the Japanese Circulation Society 76(4), 884-890, 2012-03-25

    一般社団法人 日本循環器学会

参考文献:  32件中 1-32件 を表示

被引用文献:  1件中 1-1件 を表示

各種コード

  • NII論文ID(NAID)
    10030131175
  • NII書誌ID(NCID)
    AA11591968
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13469843
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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