Coronary Slow Flow : Prevalence and Clinical Correlations

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著者

    • HAWKINS Beau M.
    • Section of Cardiovascular Disease, Department of Internal Medicine, University of Oklahoma Health Sciences Center and Department of Veterans Affairs Medical Center
    • STAVRAKIS Stavros
    • Section of Cardiovascular Disease, Department of Internal Medicine, University of Oklahoma Health Sciences Center and Department of Veterans Affairs Medical Center
    • ROUSAN Talla A.
    • Section of Cardiovascular Disease, Department of Internal Medicine, University of Oklahoma Health Sciences Center and Department of Veterans Affairs Medical Center
    • ABU-FADEL Mazen
    • Section of Cardiovascular Disease, Department of Internal Medicine, University of Oklahoma Health Sciences Center and Department of Veterans Affairs Medical Center
    • SCHECHTER Eliot
    • Section of Cardiovascular Disease, Department of Internal Medicine, University of Oklahoma Health Sciences Center and Department of Veterans Affairs Medical Center

抄録

<b><i>Background:</i></b> Coronary slow flow phenomenon (CSFP) is defined as delayed coronary opacification in the absence of obstructive coronary artery disease. In the present study, we sought to define its prevalence and clinical features. <b><i>Methods and Results:</i></b> The 1,741 consecutive patients who underwent coronary angiography (CAG) were identified. Those with normal left ventricular ejection fraction and normal coronary arteries were included in the study (n=158). TIMI frame counts were calculated, and data on demographics, comorbidities, and medication use were collected. CSFP was defined as frame count >27. Multivariate logistic regression analysis was used to identify independent predictors of CSFP. CSFP was identified in 96 (5.5%) subjects referred for CAG. Subjects with CSFP were more obese (body mass index [BMI] 33.9 vs. 29.8kg/m<sup>2</sup>, P=0.003) and had lower high-density lipoprotein levels (39.7 vs. 45.7mg/dl, P=0.04). In the CSFP group, total cholesterol, low-density lipoprotein and frame counts increased significantly with increasing vessel involvement (1-, vs. 2-, vs. 3-vessel involvement; P<0.05 for each variable). By multivariate analysis, male sex (odds ratio 3.36, 95% confidence interval 1.17-8.61, P=0.02) and higher BMI independently predicted the presence of CSFP (odds ratio 1.09, 95% confidence interval 1.03-1.15, P=0.003). <b><i>Conclusions:</i></b> CSFP is associated with male sex and obesity. Multivessel involvement may be a marker of more severe, diffuse disease. Further studies are needed to investigate this hypothesis. (<i>Circ J</i> 2012; <b>76:</b> 936-942)<br>

収録刊行物

  • Circulation journal : official journal of the Japanese Circulation Society

    Circulation journal : official journal of the Japanese Circulation Society 76(4), 936-942, 2012-03-25

    一般社団法人 日本循環器学会

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各種コード

  • NII論文ID(NAID)
    10030131425
  • NII書誌ID(NCID)
    AA11591968
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13469843
  • データ提供元
    CJP書誌  J-STAGE 
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