Effects of H_2S on Myogenic Responses in Rat Cerebral Arterioles

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著者

    • LIU Lei
    • Department of Physiology, Xuzhou Medical College
    • LIU Hong
    • Department of Pathology, Xuzhou Medical College
    • SUN Dong
    • Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical College
    • QIAO Weili
    • Department of Physiology, Xuzhou Medical College
    • QI Youjian
    • Department of Physiology, Xuzhou Medical College
    • SUN Hong
    • Department of Physiology, Xuzhou Medical College

抄録

<b><i>Background:</i></b> The potential biological significance of hydrogen sulfide (H<sub>2</sub>S) has attracted growing interests in recent years, but its role in the myogenic response of rat cerebral arterioles has not been explored. <b><i>Methods and Results:</i></b> Rats were injected with NaHS (an H<sub>2</sub>S donor, 2-200μmol·kg<sup>-1</sup>·day<sup>-1</sup>, i.p.) or saline for 3 weeks. MBP was measured with a tail-cuff method. Cerebral arterioles were isolated and cannulated in an organ bath system, and vessel diameters were measured with an image-shearing device. Changes in diameter in response to stepwise increases in intravascular pressure (20-120mmHg) were investigated under no-flow conditions. After the treatments, plasma H<sub>2</sub>S increased and MBP decreased significantly. NaHS reduced the myogenic response in a dose-dependent manner. This effect was markedly attenuated by glibenclamide, a K<sub>ATP</sub> channel blocker. Blockade of nitric oxide (NO) production with NG-nitro-L-arginine methyl ester (L-NAME, a NO synthase inhibitor) enhanced, whereas removal of the endothelium abolished the inhibitory role of NaHS on the myogenic response. <b><i>Conclusions:</i></b> For the first time it has been demonstrated that H<sub>2</sub>S decreases the myogenic response of cerebral arterioles in vivo, and this effect is endothelium-dependent and partially mediated by K<sub>ATP</sub> channels. (<i>Circ J</i> 2012; <b>76:</b> 1012-1019)<br>

収録刊行物

  • Circulation journal : official journal of the Japanese Circulation Society

    Circulation journal : official journal of the Japanese Circulation Society 76(4), 1012-1019, 2012-03-25

    一般社団法人 日本循環器学会

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各種コード

  • NII論文ID(NAID)
    10030131741
  • NII書誌ID(NCID)
    AA11591968
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13469843
  • データ提供元
    CJP書誌  J-STAGE 
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