Reversible Left Ventricular Diastolic Dysfunction on Doppler Tissue Imaging Predicts a More Favorable Prognosis in Chronic Heart Failure

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著者

    • LEE Cheng-Hung
    • Second Section of Cardiology, Department of Internal Medicine, Heart Failure Center, Chang Gung Memorial Hospital, Linkou, and Chang Gung University College of Medicine
    • HUNG Kuo-Chun
    • Second Section of Cardiology, Department of Internal Medicine, Heart Failure Center, Chang Gung Memorial Hospital, Linkou, and Chang Gung University College of Medicine
    • CHANG Shang-Hung
    • Second Section of Cardiology, Department of Internal Medicine, Heart Failure Center, Chang Gung Memorial Hospital, Linkou, and Chang Gung University College of Medicine
    • LIN Fun-Chung
    • Second Section of Cardiology, Department of Internal Medicine, Heart Failure Center, Chang Gung Memorial Hospital, Linkou, and Chang Gung University College of Medicine
    • HSIEH Ming-Jer
    • Second Section of Cardiology, Department of Internal Medicine, Heart Failure Center, Chang Gung Memorial Hospital, Linkou, and Chang Gung University College of Medicine
    • CHEN Chun-Chi
    • Second Section of Cardiology, Department of Internal Medicine, Heart Failure Center, Chang Gung Memorial Hospital, Linkou, and Chang Gung University College of Medicine
    • CHU Chi-Ming
    • Section of Health Informatics, Institute of Public Health, National Defense Medical Centre and University
    • HSIEH I-Chang
    • Second Section of Cardiology, Department of Internal Medicine, Heart Failure Center, Chang Gung Memorial Hospital, Linkou, and Chang Gung University College of Medicine
    • WEN Ming-Shien
    • Second Section of Cardiology, Department of Internal Medicine, Heart Failure Center, Chang Gung Memorial Hospital, Linkou, and Chang Gung University College of Medicine
    • WU Delon
    • Second Section of Cardiology, Department of Internal Medicine, Heart Failure Center, Chang Gung Memorial Hospital, Linkou, and Chang Gung University College of Medicine

抄録

<b><i>Background:</i></b> Early (e')/late (a') diastolic mitral annular velocity ratio is a powerful independent predictor of poor prognosis in patients with left ventricular (LV) dysfunction. Doppler tissue imaging, however, may change over time according to intervention and medical treatment. The aim of the present study was to prospectively evaluate whether, in clinically stable patients with chronic heart failure (CHF), the decrease of an initially high e'/a' ratio on long-term therapy predicts a more favorable outcome. <b><i>Methods and Results:</i></b> One hundred and eighty-one adult patients with CHF and high e'/a' ratio (≥0.74) underwent repeat echocardiography 6 months after the initial examination, and were then followed up for a mean period of 20 months. After 6 months, e'/a' ratio did not change in 95 patients, whereas it was significantly decreased (<0.74) in the remaining 86 patients. During follow-up, 55 participants (30%) had cardiac events. According to multivariate Cox regression analysis, decrease in e'/a' ratio, initial New York Heart Association class III or IV, and change in LV mass index as well as in systolic mitral annular velocities emerged as independent predictors of survival. <b><i>Conclusions:</i></b> The decrease of an initially high e'/a' ratio on long-term therapy predicts a more favorable outcome in clinically stable patients with CHF. (<i>Circ J</i> 2012; <b>76:</b> 1145-1150)<br>

収録刊行物

  • Circulation journal : official journal of the Japanese Circulation Society

    Circulation journal : official journal of the Japanese Circulation Society 76(5), 1145-1150, 2012-04-25

    一般社団法人 日本循環器学会

参考文献:  37件中 1-37件 を表示

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各種コード

  • NII論文ID(NAID)
    10030132454
  • NII書誌ID(NCID)
    AA11591968
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13469843
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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