Normal Values of Real-Time 3-Dimensional Echocardiographic Parameters in a Healthy Japanese Population : The JAMP-3D Study

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    • WATANABE Hiroyuki
    • Department of Cardiology, Sakakibara Heart Institute, Japan Research Promotion Society of Cardiovascular Disease
    • DAIMON Masao
    • Department of Cardiology, Juntendo University School of Medicine
    • ABE Yukio
    • Department of Cardiology, Osaka City General Hospital
    • ITO Hiroshi
    • Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine
    • IWAI TAKANO Masumi
    • Department of Infection Control and Laboratory Medicine, Fukushima Medical University
    • HIDAKA Takayuki
    • Department of Cardiovascular Medicine, Hiroshima University Hospital
    • YUASA Toshinori
    • Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University
    • NAKATANI Satoshi
    • Department of Health Sciences, Osaka University Graduate School of Medicine
    • NEGISHI Kazuaki
    • Department of Medicine and Biological Science, Gunma University Graduate School of Medicine
    • NISHIKAGE Tomoko
    • Department of Physiological Laboratory, Osaka Seamen's Insurance Hospital
    • SAKATA Konomi
    • Second Department of Internal Medicine, Kyorin University of Medicine
    • YAMADA Satoshi
    • Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine
    • YAMAMOTO Kazuhiro
    • Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine


<b><i>Background:</i></b> The recently developed real-time 3-dimensional echocardiography (RT3DE) is a promising imaging method to quantify cardiac chamber volumes and their functions in clinical practice. However, normal reference values of RT3DE parameters have not been fully investigated in a large, healthy Japanese population. <b><i>Methods and Results:</i></b> This study consisted of 410 healthy subjects aged from 20 to 69 years who had a RT3DE at one of the 23 collaborating institutions. All subjects had no history of cardiac disease and no risk factors. The mean values in men and women were as follows: 50±12ml/m<sup>2</sup> and 46±9ml/m<sup>2</sup> for left ventricular (LV) end-diastolic volume index, 19±5ml/m<sup>2</sup> and 17±4ml/m<sup>2</sup> for end-systolic volume index, 61±4% and 63±4% for ejection fraction, 64±12g/m<sup>2</sup> and 56±11g/m<sup>2</sup> for mass index, 23±6ml/m<sup>2</sup> and 24±6ml/m<sup>2</sup> for left atrial (LA) maximum volume index, 10±3ml/m<sup>2</sup> and 10±3ml/m<sup>2</sup> for minimum volume index, and 58±6% and 58±6% for percent volume change. LV sizes decreased with age, whereas LV mass index did not change. LA sizes slightly increased with age. <b><i>Conclusions:</i></b> This multicenter investigation determined normal reference values for LV and LA sizes, and their functional parameters on RT3DE in a large, healthy Japanese population. The results of the present study support the use of RT3DE for the diagnosis and management of cardiovascular disease. (<i>Circ J</i> 2012; <b>76:</b> 1177-1181)<br>


  • Circulation Journal

    Circulation Journal 76(5), 1177-1181, 2012-04-25

    The Japanese Circulation Society

References:  27

Cited by:  1


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