Assessment of Doxorubicin Cardiac Toxicity Using Gated ^<99m>Tc-Hexakis-2-Methoxyisobutylisonitrile Myocardial Single Photon Emission Computed Tomography : Wall Thickening and Motion Abnormalities Can Be an Early Sign of Cardiac Involvement

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著者

    • WAKABAYASHI Hiroshi
    • Department of Biotracer Medicine, Kanazawa University Graduate School of Medical Sciences
    • TAKI Junichi
    • Department of Nuclear Medicine, Kanazawa University Hospital
    • INAKI Anri
    • Department of Biotracer Medicine, Kanazawa University Graduate School of Medical Sciences
    • KINUYA Seigo
    • Department of Nuclear Medicine, Kanazawa University Hospital

抄録

<b><i>Background:</i></b> Advancement in chemotherapy has significantly improved the prognosis of cancer patients. However, many anticancer drugs have serious cardiovascular side effects. We assessed doxorubicin-induced cardiac toxicity (DCT) during and after preoperative chemotherapy using gated <sup>99m</sup>Tc-hexakis-2-methoxyisobutylisonitrile (MIBI) single photon emission computed tomography (SPECT) in patients with malignant bone and soft tissue tumors. <b><i>Methods and Results:</i></b> Gated <sup>99m</sup>Tc-MIBI SPECT was performed before, and after the middle and final courses of preoperative chemotherapy. Gated <sup>99m</sup>Tc-MIBI SPECT was quantitatively analyzed with QGS/QPS software. We also assessed the reproducibility of measurements of global and regional functions from gated SPECT images. Twenty-eight patients (19 males and 9 females), eligible for preoperative chemotherapy, were included. All patients had normal myocardial perfusion images based on QPS during preoperative chemotherapy. Wall thickening (WT) and motion (WM) decreased after the middle course of preoperative chemotherapy compared to baseline. After the final course of preoperative chemotherapy, significant decreases of ejection fraction, WT and WM, and one-third mean filling rate were observed compared to baseline. By regression analysis, correlation coefficients of inter- and intra-observer reproducibility of global and regional functions were excellent (r≥0.95). <b><i>Conclusions:</i></b> Gated <sup>99m</sup>Tc-MIBI SPECT can monitor the deterioration of cardiac function in asymptomatic patients with possible DCT. WT and WM might be useful as early markers of ventricular dysfunction due to DCT. (<i>Circ J</i> 2012; <b>76:</b> 1190-1196)<br>

収録刊行物

  • Circulation journal : official journal of the Japanese Circulation Society

    Circulation journal : official journal of the Japanese Circulation Society 76(5), 1190-1196, 2012-04-25

    一般社団法人 日本循環器学会

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各種コード

  • NII論文ID(NAID)
    10030132674
  • NII書誌ID(NCID)
    AA11591968
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13469843
  • データ提供元
    CJP書誌  J-STAGE 
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