Influence of Achieved Low-Density Lipoprotein Cholesterol Level With Atorvastatin Therapy on Stabilization of Coronary Plaques : Sub-Analysis of the TWINS Study

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著者

    • TAKAYAMA Tadateru
    • Division of Cardiology, Department of Medicine, Nihon University, School of Medicine
    • HONYE Junko
    • Department of Cardiology, Fuchu Keijin-kai Hospital
    • KOMATSU Sei
    • Cardiovascular Division, Amagasaki Central Hospital
    • YAMAGUCHI Osamu
    • Department of Cardiovascular Medicine, Osaka University, Graduate School of Medicine
    • LI Yuxin
    • Department of Advanced Cardiovascular Imaging, Nihon University School of Medicine
    • YAJIMA Junji
    • Department of Cardiology, The Cardiovascular Institute Hospital
    • TAKAZAWA Kenji
    • Department of Cardiology, Tokyo Medical University Hachioji Medical Center
    • NANTO Shinsuke
    • Department of Advanced Cardiovascular Therapeutics, Osaka University, Graduate School of Medicine
    • SAITO Satoshi
    • Division of Cardiology, Department of Medicine, Nihon University, School of Medicine
    • HIRAYAMA Atsushi
    • Division of Cardiology, Department of Medicine, Nihon University, School of Medicine

抄録

<b><i>Background:</i></b> Previously the stabilization of coronary plaque with atorvastatin was demonstrated in the TWINS (evaluaTion With simultaneous angIoscopy and iNtravascular ultraSound) study. The influence of the low-density lipoprotein cholesterol (LDL-C) level on plaque stabilization was analyzed. <b><i>Methods and Results:</i></b> Patients (n=29) with hypercholesterolemia and coronary artery disease (CAD) were analyzed. They received atorvastatin (10-20mg/day) for 80 weeks and were divided into low (<91mg/dl) and high (≥91mg/dl) LDL-C groups based on their 80-week LDL-C level. Angioscopy was performed before and after treatment. Yellow coronary plaques were classified into six grades (grades 0 to 5) and mean grade was determined for each patient. The LDL-C levels at week 28 and 80 were reduced in both low LDL-C groups (n=14, 140.3 to 77.9 and 75.9mg/dl; P<0.001 both groups) and high LDL-C groups (n=15, 151.7 to 93.0 and 99.1mg/dl; P<0.001 both groups). Significant improvement in the mean grade was shown in the low LDL-C groups (1.44 to 1.00 and 1.05; P=0.003 both groups) at week 28 and 80 vs. no significant change in high LDL-C groups (1.43 to 1.23 and 1.28; P=0.032 and P=0.169 respectively). <b><i>Conclusions:</i></b> Adequate reduction of LDL-C is important for the stabilization of coronary plaques. (<i>Circ J</i> 2012; <b>76:</b> 1197-1202)<br>

収録刊行物

  • Circulation journal : official journal of the Japanese Circulation Society

    Circulation journal : official journal of the Japanese Circulation Society 76(5), 1197-1202, 2012-04-25

    一般社団法人 日本循環器学会

参考文献:  18件中 1-18件 を表示

被引用文献:  2件中 1-2件 を表示

各種コード

  • NII論文ID(NAID)
    10030132699
  • NII書誌ID(NCID)
    AA11591968
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13469843
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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