Novel Device That Produces Carbon Dioxide Mist for Myocardial Infarction Treatment in Rats

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著者

    • YAMAZAKI Takanori
    • Department of Internal Medicine and Cardiology, Osaka City University Medical School
    • NAKAMURA Yasuhiro
    • Department of Internal Medicine and Cardiology, Osaka City University Medical School
    • HANATANI Akihisa
    • Department of Internal Medicine and Cardiology, Osaka City University Medical School
    • SHIMADA Kenei
    • Department of Internal Medicine and Cardiology, Osaka City University Medical School
    • MURO Takashi
    • Department of Internal Medicine and Cardiology, Osaka City University Medical School
    • IWAO Hiroshi
    • Department of Pharmacology, Osaka City University Medical School
    • YOSHIYAMA Minoru
    • Department of Internal Medicine and Cardiology, Osaka City University Medical School

抄録

<b><i>Background:</i></b> Carbon dioxide (CO<sub>2</sub>) baths have been used to treat a variety of diseases, but developing an artificial bath of highly concentrated CO<sub>2</sub> is difficult. Here, we tried the efficacy of a novel device instead of a CO<sub>2</sub> bath. <b><i>Methods and Results:</i></b> Using a device equipped with double fluid nozzles, CO<sub>2</sub> gas and H<sub>2</sub>O were compounded and compressed at 4 barometric pressures. As a result, CO<sub>2</sub> gas was dissolved in H<sub>2</sub>O, which contained a few micrometers of CO<sub>2</sub> particles, namely, a CO<sub>2</sub> mist. Wistar rats with myocardial infarction (MI) by ligation of the left coronary artery were percutaneously administered CO<sub>2</sub> mist or CO<sub>2</sub> gas alone or no treatment for 30min daily. With regard to tissue blood flow during treatment, the group treated with CO<sub>2</sub> mist had significantly increased tissue oxygenated hemoglobin levels and tissue saturation levels, and significantly decreased deoxygenated hemoglobin levels compared with the group treated with CO<sub>2</sub> gas. After 4 weeks treatment, the group treated with CO<sub>2</sub> mist had a significantly improved ejection fraction by echocardiography compared with the untreated group. Interestingly, the group treated with CO<sub>2</sub> mist had significantly increased nitrate concentrations in serum and vascular endothelial growth factor mRNA expression levels in the myocardium compared with the untreated group. <b><i>Conclusions:</i></b> Our new mist production device may be potentially useful for the treatment of heart failure caused by MI. (<i>Circ J</i> 2012; <b>76:</b> 1203-1212)<br>

収録刊行物

  • Circulation journal : official journal of the Japanese Circulation Society

    Circulation journal : official journal of the Japanese Circulation Society 76(5), 1203-1212, 2012-04-25

    一般社団法人 日本循環器学会

参考文献:  25件中 1-25件 を表示

被引用文献:  1件中 1-1件 を表示

各種コード

  • NII論文ID(NAID)
    10030132718
  • NII書誌ID(NCID)
    AA11591968
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13469843
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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