Correlation Between Circulating Angiogenic Cell Mobilizations and Recovery of Coronary Flow Reserve in Patients With Acute Myocardial Infarction

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著者

    • JEONG Han Saem
    • Department of Cardiology, Cardiovascular Center, Korea University Anam Hospital
    • HONG Soon Jun
    • Department of Cardiology, Cardiovascular Center, Korea University Anam Hospital
    • PARK Jae Hyoung
    • Department of Cardiology, Cardiovascular Center, Korea University Anam Hospital
    • KIM Jong-Ho
    • Department of Cardiology, Cardiovascular Center, Korea University Anam Hospital
    • CHOI Seung Cheol
    • Department of Cardiology, Cardiovascular Center, Korea University Anam Hospital
    • AHN Chul-Min
    • Department of Cardiology, Cardiovascular Center, Korea University Anam Hospital
    • KIM Je Sang
    • Department of Cardiology, Cardiovascular Center, Korea University Anam Hospital
    • LIM Do-Sun
    • Department of Cardiology, Cardiovascular Center, Korea University Anam Hospital

抄録

<b><i>Background:</i></b> The correlations between circulating angiogenic cell mobilizations and improvement of microvascular integrity were investigated in patients (n=110) with acute myocardial infarction (AMI) during an 8-month follow up. <b><i>Methods and Results:</i></b> Coronary flow reserve (CFR) was measured at baseline and at 8 months by using an intracoronary Doppler wire. Serial changes in the absolute numbers of circulating angiogenic cells such as CD34+, CXCR4+, CD117+, CD133+ and C-met+ were measured at baseline, day 1, day 5 and at 8 months. The absolute numbers of circulating angiogenic cells at day 1 were significantly higher than those at baseline. A positive correlation was found between the numbers of circulating angiogenic cells of CD34+, CXCR4+, CD117+ and CD133+ cells at day 1 and the CFR changes from baseline. The cut-off value of CFR changes at 8 months by a receiver operating characteristic curve between a circulating CD34+ cell at day 1 and changes of CFR at 8 months was 0. Late-loss showed the positive correlation with the absolute number of C-met+ cells and the negative correlation with the absolute number of CXCR4+ cells after AMI. The negative correlation was found between changes in high-sensitive C-reactive protein and soluble intercellular adhesion molecule-1 and changes in CFR at 8 months. <b><i>Conclusions:</i></b> The recovery of microvascular integrity after acute ischemic injury was expedited by the increases in circulating angiogenic cell mobilization together with the greater decreases in inflammatory cytokines. The improvement in CFR could be predicted by the measurement of circulating angiogenic cells after AMI. (<i>Circ J</i> 2012; <b>76:</b> 1213-1221)<br>

収録刊行物

  • Circulation journal : official journal of the Japanese Circulation Society

    Circulation journal : official journal of the Japanese Circulation Society 76(5), 1213-1221, 2012-04-25

    The Japanese Circulation Society

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各種コード

  • NII論文ID(NAID)
    10030132744
  • NII書誌ID(NCID)
    AA11591968
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13469843
  • データ提供元
    CJP書誌  J-STAGE 
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