Comparison of the Clinical Presentation, Treatment, and Outcome of Fulminant and Acute Myocarditis in Children

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著者

    • SAJI Tsutomu
    • The Scientific Committee, Japanese Society of Pediatric Cardiology & Cardiac Surgery
    • HASEGAWA Kei
    • Department of Pediatrics, Toho University Medical Center, Omori Hospital
    • OHKI Hirotaka
    • Department of Cardiology, Tokyo Metropolitan Children's Medical Center
    • JOO Kunio
    • Department of Pediatrics, Kyushu Kosei Nenkin Hospital
    • NAKAZAWA Makoto
    • The Scientific Committee, Japanese Society of Pediatric Cardiology & Cardiac Surgery

抄録

<b><i>Background:</i></b> Myocarditis (MC) is an important cause of cardiac dysfunction in children. Fulminant MC is sometimes fatal, and sequelae may develop during follow-up. We conducted a nationwide survey to determine the clinico-epidemiological features of MC in Japanese children and adolescents. <b><i>Methods and Results:</i></b> Survey questionnaires were mailed to 627 hospitals, which were asked if they had treated MC patients aged between 1 month and 17 years during the period from January 1997 through December 2002. Responses were collected until December 2005, and data were collected and analyzed until January 2008. A total of 169 patients were reported: 64 fulminant cases, 89 acute cases, and 8 chronic cases. Incidence was 43.5 cases/year and 0.26 cases/100,000. Pathogens were identified in 37 patients; coxsackie virus accounted for 60%. Major cardiovascular manifestations at onset were congestive heart failure, refractory arrhythmia, and syncope in 70, 37, and 17 patients, respectively. Intravenous immunoglobulin was administered to 73 patients. Mechanical support seemed to be effective and life-saving. Among the 169 patients, 123 survived. Cardiovascular sequelae were reported in 49 patients. <b><i>Conclusions:</i></b> The survival rate for children with fulminant MC was disappointing. Overall, two-thirds of survivors had no sequelae. Mechanical support may reduce the mortality and the risk of clinical worsening. (<i>Circ J</i> 2012; <b>76:</b> 1222-1228)<br>

収録刊行物

  • Circulation journal : official journal of the Japanese Circulation Society

    Circulation journal : official journal of the Japanese Circulation Society 76(5), 1222-1228, 2012-04-25

    一般社団法人 日本循環器学会

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各種コード

  • NII論文ID(NAID)
    10030132778
  • NII書誌ID(NCID)
    AA11591968
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13469843
  • データ提供元
    CJP書誌  J-STAGE 
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