Neovascularization and Angiogenic Factors in Advanced Human Carotid Artery Stenosis

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著者

    • PELISEK Jaroslav
    • Clinic of Vascular Surgery, Klinikum rechts der Isar der Technischen Universitaet Muenchen
    • WELL Georg
    • Clinic of Vascular Surgery, Klinikum rechts der Isar der Technischen Universitaet Muenchen
    • REEPS Christian
    • Clinic of Vascular Surgery, Klinikum rechts der Isar der Technischen Universitaet Muenchen
    • RUDELIUS Martina
    • Institute of Pathology, Klinikum rechts der Isar der Technischen Universitaet Muenchen
    • KUEHNL Andreas
    • Clinic of Vascular Surgery, Klinikum rechts der Isar der Technischen Universitaet Muenchen
    • CULMES Mihaela
    • Clinic of Vascular Surgery, Klinikum rechts der Isar der Technischen Universitaet Muenchen
    • POPPERT Holger
    • Institute of Neurology, Klinikum rechts der Isar der Technischen Universitaet Muenchen
    • ZIMMERMANN Alexander
    • Clinic of Vascular Surgery, Klinikum rechts der Isar der Technischen Universitaet Muenchen
    • BERGER Hermann
    • Department of Radiology, Klinikum rechts der Isar der Technischen Universitaet Muenchen

抄録

<b><i>Background:</i></b> Most atherosclerotic lesions are vascularized, so neovessels may also contribute to plaque progression and vulnerability, but their precise role of neovessels in atherosclerosis is still unknown. The aim of this study was to analyze the possible relationships among neovascularization, relevant angiogenic factors, and plaque vulnerability in patients with advanced carotid artery stenosis. <b><i>Methods and Results:</i></b> The study group comprised 56 patients (stable: n=28, unstable: n=28) with advanced carotid artery stenosis (>70%). Immunohistochemistry was performed for smooth muscle, endothelial, and inflammatory cells, macrophages, vascular endothelial growth factor (VEGF), VEGF receptor-2 (VEGFR-2), platelet-derived growth factor (PDGF), and angiopoietin-1,-2 (Ang-1,-2). Furthermore, the concentrations of angiogenic factors were measured in serum. Quantitative expression analysis was performed by SYBR-Green-based real-time polymerase chain reaction. Compared with stable carotid lesions, unstable carotid lesions showed 1.8-fold increase in neovascularization (P=0.013), which significantly correlated with accumulation of inflammatory cells (factor 1.9, P<0.001). In unstable lesions, compared with stable lesions, VEGF was 1.7-fold increased (P=0.032) and Ang-1 was 1.9-fold reduced (P=0.029). Furthermore, VEGF was higher in the blood of patients with unstable plaques than in stable plaques (0.32±0.22 vs. 0.22±0.16ng/ml; P=0.002). Significant correlations were observed between plaque vulnerability, VEGF, neovascularization and inflammatory cells. <b><i>Conclusions:</i></b> Our results show a close association between neovascularization, expression of angiogenic factors, inflammation, and plaque vulnerability in patients with advanced carotid stenosis. (<i>Circ J</i> 2012; <b>76:</b> 1274-1282)<br>

収録刊行物

  • Circulation journal : official journal of the Japanese Circulation Society

    Circulation journal : official journal of the Japanese Circulation Society 76(5), 1274-1282, 2012-04-25

    一般社団法人 日本循環器学会

参考文献:  32件中 1-32件 を表示

被引用文献:  1件中 1-1件 を表示

各種コード

  • NII論文ID(NAID)
    10030133047
  • NII書誌ID(NCID)
    AA11591968
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13469843
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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