骨格筋とマイクロRNA MicroRNAs in skeletal muscle

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著者

    • 秋本 崇之 AKIMOTO Takayuki
    • 東京大学大学院医学系研究科 疾患生命工学センター 再生医療工学部門 Division of Regenerative Medical Engineering, Center for Disease Biology and Integrative Medicine. Graduate School of Medicine, The University of Tokyo
    • 沢田 秀司 SAWADA Shuji
    • 早稲田大学大学院 先進理工学研究科 共同先進健康科学専攻 Joint Department of Advanced Health Science, Graduate School of Advanced Science and Engineering, Waseda University

抄録

Skeletal muscle is the dominant organ in locomotion and energy metabolism so that maintaining skeletal muscle function is a prerequisite for our health and independent living throughout the life. A loss or decrease in skeletal muscle function leads to increased morbidity and mortality through the development of secondary diseases such as metabolic syndrome, type 2 diabetes, obesity, cardiovascular and respiratory disease. Identifying mechanisms which influence the processes regulating skeletal muscle function is a key priority. The recent discovery of microRNAs (miRNAs) provides a new knowledge controlling skeletal muscle function. miRNAs suppress gene expression through either in inhibition of protein translation or in degradation of the mRNA transcripts through a process similar to RNA interference (RNAi). This review provides the current understanding in skeletal muscle miRNA biology and focuses on their role and regulation under physiological conditions with exercise.

収録刊行物

  • 体力科學

    体力科學 61(1), 61-70, 2012-02-01

    一般社団法人日本体力医学会

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各種コード

  • NII論文ID(NAID)
    10030139799
  • NII書誌ID(NCID)
    AN00137986
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    0039906X
  • NDL 記事登録ID
    023513521
  • NDL 請求記号
    Z7-301
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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