骨折を伴う外固定が関節拘縮と廃用性筋萎縮に及ぼす影響 The effects of fracture fixation on joint contracture and disuse atrophy in immobilized rat soleus muscle

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抄録

In the present study, we investigated the effects of fracture fixation on joint contracture and disuse muscle atrophy. We surgically fractured the right hind limbs of male Wistar rats, and then fixed the right ankle joints at maximal plantar flexion for two weeks using dorsal splints. Compared with immobilized healthy and sham operated joints, the fractured joints concomitantly showed highly restricted range of motion and significantly higher degrees of disuse atrophy in soleus muscle; decrease of muscle fiber cross sectional area, development of central core lesion and a change in myosin heavy chain isoforms from slow type myosin to fast type myosin. Therefore, it is suggested that orthopedic fracture fixation induces intense disuse muscle atrophy to aggravate joint contracture.

収録刊行物

  • 体力科學

    体力科學 61(1), 95-101, 2012-02-01

    一般社団法人日本体力医学会

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各種コード

  • NII論文ID(NAID)
    10030140002
  • NII書誌ID(NCID)
    AN00137986
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    0039906X
  • NDL 記事登録ID
    023513725
  • NDL 請求記号
    Z7-301
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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