外部刺激を考慮した遺伝子ネットワークの最適制御 Optimal Control of Gene Regulatory Networks with External Stimuli

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著者

    • 小林 孝一 KOBAYASHI Koichi
    • 北陸先端科学技術大学院大学情報科学研究科 School of Information Science, Japan Advanced Institute of Science and Technology
    • 平石 邦彦 HIRAISHI Kunihiko
    • 北陸先端科学技術大学院大学情報科学研究科 School of Information Science, Japan Advanced Institute of Science and Technology

抄録

In this paper, the optimal control problem of gene regulatory networks modeled by Boolean networks is discussed. In the standard problem formulation, we assume that there exist genes corresponding to control inputs in gene regulatory networks. However, in many systems, this assumption is not satisfied. In this paper, two kinds of control inputs are considered. One is the above control input. The other is the control input corresponding to an external stimulus. An external stimulus does not control the detailed behavior, but can switch Boolean functions probabilistically. So genes corresponding to control inputs may not exist, and this problem formulation is more realistic. Furthermore, the optimal control problem is reduced to an integer linear programming problem.

収録刊行物

  • 計測自動制御学会論文集 = Transactions of the Society of Instrument and Control Engineers

    計測自動制御学会論文集 = Transactions of the Society of Instrument and Control Engineers 47(11), 520-526, 2011-11-30

    公益社団法人 計測自動制御学会

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各種コード

  • NII論文ID(NAID)
    10030165490
  • NII書誌ID(NCID)
    AN00072392
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    04534654
  • NDL 記事登録ID
    023446325
  • NDL 請求記号
    Z14-482
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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