ヒト Collagen における細胞選択的ペプチドの分布

DOI Web Site 参考文献22件

書誌事項

タイトル別名
  • Cell-Selective Peptide Distribution in Human Collagen Proteins
  • ヒト Collagen ニ オケル サイボウ センタクテキ ペプチド ノ ブンプ

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抄録

To reduce risks in vascular implants, the design of effective coating polymer for balancing the organization and growth of surrounding cells is important. To design such polymer by learning the mechanism of native extracellular matrix (ECM), we had investigated ECM-specific peptides with cell-selectivity to control the adhesion balance of endothelial cells (ECs) and smooth muscle cells (SMCs). From our high-throughput comparative screening using in silico analysis and peptide array screening platform, we had found that there are various types of EC-selective and SMC-selective peptides in human collagen type IV. In this report, we mapped the distribution of obtained EC-and SMC-selective peptides in the collagen, and extracted a new design policy of cell-selective polymers for medical implant surface modification.<br>

収録刊行物

  • 高分子論文集

    高分子論文集 69 (3), 129-134, 2012

    公益社団法人 高分子学会

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