Superantigenic Toxin Genes Coexist with Specific Staphylococcal Cassette Chromosome mec Genes in Methicillin-Resistant Staphylococcus aureus

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著者

    • HU Dong-Liang
    • Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine
    • MAINA Edward K
    • Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine
    • OMOE Katsuhiko
    • Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
    • INOUE Fumio
    • Department of Clinical Laboratory, Hirosaki University Hospital
    • NAKANE Akio
    • Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine

抄録

<i>Staphylococcus aureus</i> is a leading cause of human disease in the hospital setting and the community. Superantigenic toxin-producing methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) is currently important for nosocomial infections and food-borne diseases worldwide because of its global spreading and difficulty in therapy. Superantigenic toxins can bypass normal antigen presentation and have strong T cell mitogenic activity, leading to massive release of proinflammatory cytokines and contributing to the severity of <i>S. aureus</i> sepsis. In this study, a total of 131 MRSA isolates from patients in the University Hospital were searched for staphylococcal cassette chromosome <i>mec</i> (SCC<i>mec</i>) genes and the staphylococcal superantigenic toxin genes by multiplex polymerase chain reactions. The MRSA isolates were classified into SCC<i>mec</i> type II (74.8%), type I (13.0%), type IV (3.8%), type V (2.3%), and type I and type II (3.8%). MRSA isolates (102/131) also carried a number of superantigenic toxin genes including staphylococcal enterotoxin (<i>se</i>) and toxic shock syndrome toxin-1 (<i>tst-1</i>) genes. The most frequent superantigen gene profile (55/131, 42.0%) of the MRSA isolates includes staphylococcal enterotoxin C (<i>sec</i>), <i>seg</i>, <i>sei</i>, staphylococcal enterotoxin-like L (<i>sell</i>), <i>selm</i>, <i>seln</i>, <i>selo</i>, and <i>tst-1</i>. Furthermore, SCC<i>mec</i> type I or type II MRSA isolates more frequently harbor <i>sec</i>, <i>seg</i>, <i>sei</i>, <i>sell</i>, <i>selm</i>, <i>seln</i>, <i>selo</i>, and <i>tst-1</i> genes, compared to other types of MRSA. These results indicate that the selected superantigenic toxin genes are linked to SCC<i>mec</i> type I and type II. The coexistence of these toxins and the SCC<i>mec</i> genes in <i>S. aureus</i> may contribute to the biological fitness and pathogenicity of MRSA.

収録刊行物

  • Tohoku journal of experimental medicine

    Tohoku journal of experimental medicine 225(3), 161-169, 2011-11-01

    東北ジャーナル刊行会

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各種コード

  • NII論文ID(NAID)
    10030196029
  • NII書誌ID(NCID)
    AA00863920
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00408727
  • データ提供元
    CJP書誌  J-STAGE 
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