Association between Renal Dysfunction and the Mixed Plaque of Coronary Artery on Computed Tomographic Angiography

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著者

    • SUNG Jiyoon
    • Department of Internal Medicine, Gachon University School of Medicine
    • CHANG Jae Hyun
    • Department of Internal Medicine, Gachon University School of Medicine
    • CHUNG Wook-Jin
    • Department of Internal Medicine, Gachon University School of Medicine
    • JUNG Ji Yong
    • Department of Internal Medicine, Gachon University School of Medicine
    • NA Sun Young
    • Department of Internal Medicine, Gachon University School of Medicine
    • LEE Hyun Hee
    • Department of Internal Medicine, Gachon University School of Medicine
    • SUNG Yon Mi
    • Department of Radiology, Gachon University School of Medicine
    • MOON Chan Il
    • Department of Internal Medicine, Gachon University School of Medicine
    • HWANG Young-Hwan
    • Department of Internal Medicine, Eulji General Hospital, Eulji University College of Medicine
    • CHUNG Wookyung
    • Department of Internal Medicine, Gachon University School of Medicine
    • KIM Sejoong
    • Department of Internal Medicine, Seoul National University Bundang Hospital

抄録

Coronary artery plaque is related to development of coronary artery disease (CAD), and chronic kidney disease is associated with CAD. However, the association of renal dysfunction (RD) with coronary artery plaque characteristics has not been fully elucidated. We evaluated the association between RD and coronary artery plaque characteristics in patients with suspected CAD, who underwent multislice computed tomographic angiography (CTA). A total of 918 patients were classified into 4 groups: group with no plaque (NP) (48.9%), group with calcified plaque (CP) (16.0%), group with noncalcified plaque (NCP) (22.4%), and group with mixed plaque (MP) (12.7%). NCP is considered as rupture-prone soft plaque, and CP as more stable lesion. The mean of estimated glomerular filtration rate (eGFR) was 82.5 ± 15.4 mL/min/1.73m<sup>2</sup>, and the prevalence of RD (defined as eGFR < 60 mL/min/1.73m<sup>2</sup>) was 6.3%. The prevalence of RD was 3.3% in the NP group, 10.2% in the CP group, 5.3% in the NCP group, and 14.5% in the MP group (<i>P</i> < 0.001 by ANOVA tests). The adjusted odds ratio for RD was 3.38 (95% confidence interval, 1.27 - 9.04) for the MP group, compared with the NP group. The presence of RD showed an independent association with the MP counts (<i>r</i> = 0.155, <i>P</i> < 0.001); however, there was no association between RD and other plaque characteristics. In conclusion, RD is associated with MP rather than CP or NCP, compared with NP, which may reflect one of the developmental processes of CAD in patients with RD.

収録刊行物

  • Tohoku journal of experimental medicine

    Tohoku journal of experimental medicine 225(3), 171-177, 2011-11-01

    Tohoku University Medical Press

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各種コード

  • NII論文ID(NAID)
    10030196078
  • NII書誌ID(NCID)
    AA00863920
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00408727
  • データ提供元
    CJP書誌  J-STAGE 
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