Association of Nitrogen Compounds in Drinking Water with Incidence of Esophageal Squamous Cell Carcinoma in Shexian, China

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著者

    • ZHANG Nan
    • Department of Medical Informatics, Niigata University Medical and Dental Hospital
    • YU Cao
    • Fourth Affiliated Hospital of Hebei Medical University
    • WEN Denggui
    • Fourth Affiliated Hospital of Hebei Medical University
    • CHEN Jun
    • Department of Medical Informatics, Niigata University Medical and Dental Hospital
    • LING Yiwei
    • Department of Medical Informatics, Niigata University Medical and Dental Hospital
    • TERAJIMA Kenshi
    • Department of Medical Informatics, Niigata University Medical and Dental Hospital
    • AKAZAWA Kohei
    • Department of Medical Informatics, Niigata University Medical and Dental Hospital
    • SHAN Baoen
    • Fourth Affiliated Hospital of Hebei Medical University
    • WANG Shijie
    • Fourth Affiliated Hospital of Hebei Medical University

抄録

The incidence of esophageal squamous cell carcinoma (ESCC), which is the eighth most common malignancy worldwide, is highest in China. The purpose of this study was to investigate the association between nitrogen compounds in drinking water with the incidence of ESCC by geographical spatial analysis. The incidence of ESCC is high in Shexian county, China, and environmental factors, particularly nitrogen-contaminated drinking water, are the main suspected risk factors. This study focuses on three nitrogen compounds in drinking water, namely, nitrates, nitrites, and ammonia, all of which are derived mainly from domestic garbage and agricultural fertilizer. The study surveyed 48 villages in the Shexian area with a total population of 54,716 (661 adults with ESCC and 54,055 non-cancer subjects). Hot-spot analysis was used to identify spatial clusters with a high incidence of ESCC and a high concentration of nitrogen compounds. Logistic regression analysis was used to detect risk factors for ESCC incidence. Most areas with high concentrations of nitrate nitrogen in drinking water had a high incidence of ESCC. Correlation analysis revealed a significant positive relationship between nitrate concentration and ESCC (<i>P</i> = 0.01). Logistic regression analysis also confirmed that nitrate nitrogen has a significantly higher odds ratio. The results indicate that nitrate nitrogen is associated with ESCC incidence in Shexian county. In conclusion, high concentrations of nitrate nitrogen in drinking water may be a significant risk factor for the incidence of ESCC.

収録刊行物

  • Tohoku journal of experimental medicine

    Tohoku journal of experimental medicine 226(1), 11-17, 2012-01-01

    Tohoku University Medical Press

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各種コード

  • NII論文ID(NAID)
    10030196665
  • NII書誌ID(NCID)
    AA00863920
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00408727
  • データ提供元
    CJP書誌  J-STAGE 
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